Neuroblastoma SH-SY5Y cytotoxicity, anti-amyloidogenic activity and cyclooxygenase inhibition of Lasianthus trichophlebus (Rubiaceae)
DC Field | Value | Language |
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dc.contributor.author | Tan M.A. | - |
dc.contributor.author | Lagamayo M.W.D. | - |
dc.contributor.author | Alejandro G.J.D. | - |
dc.contributor.author | An S.S.A. | - |
dc.date.available | 2020-04-06T07:37:56Z | - |
dc.date.created | 2020-04-02 | - |
dc.date.issued | 2020-03 | - |
dc.identifier.issn | 2190-572X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/26415 | - |
dc.description.abstract | The anti-amyloidogenic potential and cyclooxygenase anti-inflammatory activity of Lasianthus trichophlebus extracts were evaluated. The MeOH extract (LTM) and chloroform extract (LTC) exhibited significant cytotoxic inhibition against the neuroblastoma SH-SY5Y cell with an IC50 of 17.52 μg/mL and 12.28 μg/mL, respectively. Thioflavin T assay indicated the LTC extract inhibition (70.56% at 50 μg/mL) to be statistically comparable (p < 0.05) to the positive control. Cyclooxygenase inhibition against COX-1 and COX-2 enzymes gave IC50 values for the LTM extract to be 18.20 and 29.60 µg/mL, respectively; while, the LTC extract showed 4.11 and 2.78 µg/mL, respectively. LC–MS of the LTM extract identified 22 putative compounds, which may prove to be pharmacologically relevant. This study has provided potential insights into the utilization of L. trichophlebus to develop safer plant-based agents for anti-inflammatory or neurodegenerative diseases. © 2020, King Abdulaziz City for Science and Technology. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Springer | - |
dc.relation.isPartOf | 3 Biotech | - |
dc.title | Neuroblastoma SH-SY5Y cytotoxicity, anti-amyloidogenic activity and cyclooxygenase inhibition of Lasianthus trichophlebus (Rubiaceae) | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000526726500003 | - |
dc.identifier.doi | 10.1007/s13205-020-2145-2 | - |
dc.identifier.bibliographicCitation | 3 Biotech, v.10, no.4 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85080977843 | - |
dc.citation.title | 3 Biotech | - |
dc.citation.volume | 10 | - |
dc.citation.number | 4 | - |
dc.contributor.affiliatedAuthor | Tan M.A. | - |
dc.contributor.affiliatedAuthor | An S.S.A. | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Cyclooxygenase | - |
dc.subject.keywordAuthor | Cytotoxicity | - |
dc.subject.keywordAuthor | Lasianthus | - |
dc.subject.keywordAuthor | Neuroblastoma | - |
dc.subject.keywordPlus | amyloid beta protein[1-42] | - |
dc.subject.keywordPlus | antiinflammatory agent | - |
dc.subject.keywordPlus | cyclooxygenase 1 | - |
dc.subject.keywordPlus | cyclooxygenase 2 | - |
dc.subject.keywordPlus | indometacin | - |
dc.subject.keywordPlus | Lasianthus trichophlebus extract | - |
dc.subject.keywordPlus | phenolsulfonphthalein | - |
dc.subject.keywordPlus | plant extract | - |
dc.subject.keywordPlus | prostaglandin synthase inhibitor | - |
dc.subject.keywordPlus | thioflavine | - |
dc.subject.keywordPlus | unclassified drug | - |
dc.subject.keywordPlus | Alzheimer disease | - |
dc.subject.keywordPlus | antiinflammatory activity | - |
dc.subject.keywordPlus | Article | - |
dc.subject.keywordPlus | cell viability | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | drug cytotoxicity | - |
dc.subject.keywordPlus | enzyme inhibition | - |
dc.subject.keywordPlus | IC50 | - |
dc.subject.keywordPlus | in vitro study | - |
dc.subject.keywordPlus | Lasianthus trichophlebus | - |
dc.subject.keywordPlus | liquid chromatography-mass spectrometry | - |
dc.subject.keywordPlus | metabolic fingerprinting | - |
dc.subject.keywordPlus | N9 cell line | - |
dc.subject.keywordPlus | neuroblastoma cell | - |
dc.subject.keywordPlus | oxidative stress | - |
dc.subject.keywordPlus | Parkinson disease | - |
dc.subject.keywordPlus | plant leaf | - |
dc.subject.keywordPlus | priority journal | - |
dc.subject.keywordPlus | Rubiaceae | - |
dc.subject.keywordPlus | SH-SY5Y cell line | - |
dc.subject.keywordPlus | traumatic brain injury | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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