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Four new pregnane glycosides from Gymnema latifolium and their alpha-glucosidase and alpha-amylase inhibitory activities
- Authors
- Yen, Duong Thi Hai; Trang, Do Thi; Tai, Bui Huu; Doan, Vu Van; Yen, Pham Hai; Nhiem, Nguyen Xuan; Van Minh, Chau; Hoang Duc, Manh; Park, SeonJu; Lee, Jae Hyuk; Kim, Sun Yeou; Kim, Seung Hyun; Kiem, Phan Van
- Issue Date
- Nov-2021
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- Gymnema latifolium; alpha-glucosidase; alpha-amylase; gymlatifoside A; gymlatifoside B; gymlatifoside C; gymlatifoside D
- Citation
- NATURAL PRODUCT RESEARCH, v.35, no.22, pp.4460 - 4467
- Journal Title
- NATURAL PRODUCT RESEARCH
- Volume
- 35
- Number
- 22
- Start Page
- 4460
- End Page
- 4467
- ISSN
- 1478-6419
- Abstract
- Four new pregnane glycosides, gymlatifosides A - D (1 - 4) and one known pregnane glycoside, verticilloside J (5) were isolated from the leaves of Gymnema latifolium Wall. ex Wight. Their chemical structures were elucidated on the basis of extensive spectroscopic methods, including 1D, 2D NMR, HR-ESI-MS, and in comparison with the reported data. All these compounds were tested for alpha-glucosidase and alpha-amylase inhibitory activities. Compound 5 exhibited the most anti alpha-glucosidase activity with inhibitory percentage of 37.8 +/- 1.5% at the concentration of 200 mu M. Compounds 1-4 showed moderate anti alpha-glucosidase activity with inhibitory percentage ranging from 7.0 to 30.1%. In addition, all compounds 1-5 showed moderate/weak anti alpha-amylase activity in the investigated test. [GRAPHICS] .
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Related Researcher
- Kim, Sun Yeou
- Pharmacy (Dept.of Pharmacy)