Taurine-Rich-Containing Hot Water Extract of Loliolus Beka Gray Meat Scavenges Palmitate-Induced Free Radicals and Protects Against DNA Damage in Insulin Secreting β-Cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cha, Seon-Heui | - |
dc.contributor.author | Han, Eui Jeong | - |
dc.contributor.author | Ahn, Ginnae | - |
dc.contributor.author | Jun, Hee-Sook | - |
dc.date.available | 2020-04-21T06:35:16Z | - |
dc.date.created | 2020-04-21 | - |
dc.date.issued | 2019-11 | - |
dc.identifier.issn | 0065-2598 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/27827 | - |
dc.description.abstract | The loss of pancreatic β-cells plays a central role in the pathogenesis of both type 1 and type 2 diabetes, and many studies have been focused on ways to improve glucose homeostasis by preserving, expanding and improving the function of β-cell. Elevated levels of free fatty acids such as palmitate might contribute to the loss of β-cells. A marine squid, Loliolus beka has long been used as a food in Korea, China, Japan and Europe due to its tender meat and high taurine content. Here, we investigated the protective effects of a hot water extract of Loliolus beka meat (LBM) against palmitate toxicity in Ins-1 cells, a rat β-cell line. Treatment with LBM extract protected against palmitate-induced cytotoxicity and scavenged overproduction of nitric oxide, alkyl, and hydroxyl radicals. In addition, LBM extract protected against palmitate-induced DNA damage and β-cell dysfunction. These findings suggest that LBM protects pancreatic β-cells from palmitate-induced damage. LBM could be a potential therapeutic functional food for diabetes. © 2019, Springer Nature Singapore Pte Ltd. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER INTERNATIONAL PUBLISHING AG | - |
dc.relation.isPartOf | TAURINE 11 | - |
dc.title | Taurine-Rich-Containing Hot Water Extract of Loliolus Beka Gray Meat Scavenges Palmitate-Induced Free Radicals and Protects Against DNA Damage in Insulin Secreting β-Cells | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000514085100046 | - |
dc.identifier.doi | 10.1007/978-981-13-8023-5_45 | - |
dc.identifier.bibliographicCitation | TAURINE 11, v.1155, pp.483 - 495 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85071751476 | - |
dc.citation.endPage | 495 | - |
dc.citation.startPage | 483 | - |
dc.citation.title | TAURINE 11 | - |
dc.citation.volume | 1155 | - |
dc.contributor.affiliatedAuthor | Jun, Hee-Sook | - |
dc.type.docType | Book Chapter | - |
dc.subject.keywordAuthor | Beta-cell | - |
dc.subject.keywordAuthor | Diabetes | - |
dc.subject.keywordAuthor | Loliolus beka | - |
dc.subject.keywordAuthor | Loliolus beka meat | - |
dc.subject.keywordAuthor | Seaweed | - |
dc.subject.keywordAuthor | Taurine | - |
dc.subject.keywordPlus | alkyl radical | - |
dc.subject.keywordPlus | amino acid | - |
dc.subject.keywordPlus | free radical | - |
dc.subject.keywordPlus | hydroxyl radical | - |
dc.subject.keywordPlus | insulin | - |
dc.subject.keywordPlus | Loliolus beka extract | - |
dc.subject.keywordPlus | nitric oxide | - |
dc.subject.keywordPlus | palmitic acid | - |
dc.subject.keywordPlus | taurine | - |
dc.subject.keywordPlus | tissue extract | - |
dc.subject.keywordPlus | unclassified drug | - |
dc.subject.keywordPlus | water | - |
dc.subject.keywordPlus | cell extract | - |
dc.subject.keywordPlus | free radical | - |
dc.subject.keywordPlus | palmitic acid derivative | - |
dc.subject.keywordPlus | taurine | - |
dc.subject.keywordPlus | amino acid composition | - |
dc.subject.keywordPlus | animal cell | - |
dc.subject.keywordPlus | animal tissue | - |
dc.subject.keywordPlus | antioxidant activity | - |
dc.subject.keywordPlus | cell level | - |
dc.subject.keywordPlus | cell protection | - |
dc.subject.keywordPlus | cell viability | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | cytotoxicity | - |
dc.subject.keywordPlus | DNA damage | - |
dc.subject.keywordPlus | DNA strand breakage | - |
dc.subject.keywordPlus | functional food | - |
dc.subject.keywordPlus | INS-1 cell line | - |
dc.subject.keywordPlus | insulin release | - |
dc.subject.keywordPlus | nonhuman | - |
dc.subject.keywordPlus | priority journal | - |
dc.subject.keywordPlus | rat | - |
dc.subject.keywordPlus | squid | - |
dc.subject.keywordPlus | animal | - |
dc.subject.keywordPlus | apoptosis | - |
dc.subject.keywordPlus | cell line | - |
dc.subject.keywordPlus | chemistry | - |
dc.subject.keywordPlus | Decapodiformes | - |
dc.subject.keywordPlus | diabetes mellitus | - |
dc.subject.keywordPlus | drug effect | - |
dc.subject.keywordPlus | meat | - |
dc.subject.keywordPlus | pancreas islet beta cell | - |
dc.subject.keywordPlus | Animals | - |
dc.subject.keywordPlus | Apoptosis | - |
dc.subject.keywordPlus | Cell Extracts | - |
dc.subject.keywordPlus | Cell Line | - |
dc.subject.keywordPlus | Decapodiformes | - |
dc.subject.keywordPlus | Diabetes Mellitus | - |
dc.subject.keywordPlus | DNA Damage | - |
dc.subject.keywordPlus | Free Radicals | - |
dc.subject.keywordPlus | Insulin-Secreting Cells | - |
dc.subject.keywordPlus | Meat | - |
dc.subject.keywordPlus | Palmitates | - |
dc.subject.keywordPlus | Rats | - |
dc.subject.keywordPlus | Taurine | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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