Taurine-Rich-Containing Hot Water Extract of Loliolus Beka Gray Meat Scavenges Palmitate-Induced Free Radicals and Protects Against DNA Damage in Insulin Secreting β-Cells
- Authors
- Cha, Seon-Heui; Han, Eui Jeong; Ahn, Ginnae; Jun, Hee-Sook
- Issue Date
- Nov-2019
- Publisher
- SPRINGER INTERNATIONAL PUBLISHING AG
- Keywords
- Beta-cell; Diabetes; Loliolus beka; Loliolus beka meat; Seaweed; Taurine
- Citation
- TAURINE 11, v.1155, pp.483 - 495
- Journal Title
- TAURINE 11
- Volume
- 1155
- Start Page
- 483
- End Page
- 495
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/27827
- DOI
- 10.1007/978-981-13-8023-5_45
- ISSN
- 0065-2598
- Abstract
- The loss of pancreatic β-cells plays a central role in the pathogenesis of both type 1 and type 2 diabetes, and many studies have been focused on ways to improve glucose homeostasis by preserving, expanding and improving the function of β-cell. Elevated levels of free fatty acids such as palmitate might contribute to the loss of β-cells. A marine squid, Loliolus beka has long been used as a food in Korea, China, Japan and Europe due to its tender meat and high taurine content. Here, we investigated the protective effects of a hot water extract of Loliolus beka meat (LBM) against palmitate toxicity in Ins-1 cells, a rat β-cell line. Treatment with LBM extract protected against palmitate-induced cytotoxicity and scavenged overproduction of nitric oxide, alkyl, and hydroxyl radicals. In addition, LBM extract protected against palmitate-induced DNA damage and β-cell dysfunction. These findings suggest that LBM protects pancreatic β-cells from palmitate-induced damage. LBM could be a potential therapeutic functional food for diabetes. © 2019, Springer Nature Singapore Pte Ltd.
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