Factors influencing insulin sensitivity during hyperinsulinemic-euglycemic clamp in healthy Korean male subjects
DC Field | Value | Language |
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dc.contributor.author | Shin, Dongseong | - |
dc.contributor.author | Eom, Young Sil | - |
dc.contributor.author | Chon, Suk | - |
dc.contributor.author | Kim, Byung-Joon | - |
dc.contributor.author | Yu, Kyung-Sang | - |
dc.contributor.author | Lee, Dae Ho | - |
dc.date.available | 2020-02-27T07:42:53Z | - |
dc.date.created | 2020-02-05 | - |
dc.date.issued | 2019-04 | - |
dc.identifier.issn | 1178-7007 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/2870 | - |
dc.description.abstract | Background and objective: The effects of age and related factors on insulin sensitivity have not been definitively evaluated in East Asian populations. We proposed a reference range for the glucose disposal rate (M-value) on hyperinsulinemic-euglycemic study and its association with other parameters. Methods: Healthy, non-diabetic young (n=10) and elderly (n=13) male subjects with normal body mass index were eligible for this study. Subjects who passed the oral glucose tolerance test (OGTT) underwent hyperinsulinemic-euglycemic clamp with high-dose (80 mU/m(2) . min) insulin infusion. Results: M-values were normalized to body weight (MBW) and fat-free mass (MFFM). Neither M-value was significantly different between age groups (P=0.458 and P=0.900, respectively). An inverse correlation was observed between MFFM and baseline insulin (r=-0.418; P=0.047), baseline C-peptide (r=-0.426; P=0.043) and OGTT 2-hour glucose (r=-0.452; P=0.030). Regarding correlations with other insulin sensitivity indices, M-values were positively associated with the Matsuda index but not with homeostasis model assessment of insulin resistance. Conclusion: Our results suggest that age is not a critical determinant of insulin sensitivity, while fasting insulin and C-peptide levels, OGTT 2-hour glucose level, and Matsuda index are predictable markers of insulin sensitivity in healthy Koreans. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | DOVE MEDICAL PRESS LTD | - |
dc.relation.isPartOf | DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY | - |
dc.title | Factors influencing insulin sensitivity during hyperinsulinemic-euglycemic clamp in healthy Korean male subjects | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000467291900001 | - |
dc.identifier.doi | 10.2147/DMSO.S195350 | - |
dc.identifier.bibliographicCitation | DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY, v.12, pp.469 - 476 | - |
dc.identifier.scopusid | 2-s2.0-85067548082 | - |
dc.citation.endPage | 476 | - |
dc.citation.startPage | 469 | - |
dc.citation.title | DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY | - |
dc.citation.volume | 12 | - |
dc.contributor.affiliatedAuthor | Shin, Dongseong | - |
dc.contributor.affiliatedAuthor | Eom, Young Sil | - |
dc.contributor.affiliatedAuthor | Kim, Byung-Joon | - |
dc.contributor.affiliatedAuthor | Lee, Dae Ho | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | insulin sensitivity | - |
dc.subject.keywordAuthor | hyperinsulinemic-euglycemic clamp | - |
dc.subject.keywordAuthor | glucose disposal rate | - |
dc.subject.keywordAuthor | age | - |
dc.subject.keywordAuthor | Matsuda index | - |
dc.subject.keywordPlus | GLUCOSE-TOLERANCE | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | INDEX | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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