Factors influencing insulin sensitivity during hyperinsulinemic-euglycemic clamp in healthy Korean male subjects
- Authors
- Shin, Dongseong; Eom, Young Sil; Chon, Suk; Kim, Byung-Joon; Yu, Kyung-Sang; Lee, Dae Ho
- Issue Date
- Apr-2019
- Publisher
- DOVE MEDICAL PRESS LTD
- Keywords
- insulin sensitivity; hyperinsulinemic-euglycemic clamp; glucose disposal rate; age; Matsuda index
- Citation
- DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY, v.12, pp.469 - 476
- Journal Title
- DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
- Volume
- 12
- Start Page
- 469
- End Page
- 476
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/2870
- DOI
- 10.2147/DMSO.S195350
- ISSN
- 1178-7007
- Abstract
- Background and objective: The effects of age and related factors on insulin sensitivity have not been definitively evaluated in East Asian populations. We proposed a reference range for the glucose disposal rate (M-value) on hyperinsulinemic-euglycemic study and its association with other parameters. Methods: Healthy, non-diabetic young (n=10) and elderly (n=13) male subjects with normal body mass index were eligible for this study. Subjects who passed the oral glucose tolerance test (OGTT) underwent hyperinsulinemic-euglycemic clamp with high-dose (80 mU/m(2) . min) insulin infusion. Results: M-values were normalized to body weight (MBW) and fat-free mass (MFFM). Neither M-value was significantly different between age groups (P=0.458 and P=0.900, respectively). An inverse correlation was observed between MFFM and baseline insulin (r=-0.418; P=0.047), baseline C-peptide (r=-0.426; P=0.043) and OGTT 2-hour glucose (r=-0.452; P=0.030). Regarding correlations with other insulin sensitivity indices, M-values were positively associated with the Matsuda index but not with homeostasis model assessment of insulin resistance. Conclusion: Our results suggest that age is not a critical determinant of insulin sensitivity, while fasting insulin and C-peptide levels, OGTT 2-hour glucose level, and Matsuda index are predictable markers of insulin sensitivity in healthy Koreans.
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