Isolation of bioactive limonoids from the fruits of Melia azedarach
DC Field | Value | Language |
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dc.contributor.author | Park, SeonJu | - |
dc.contributor.author | Nhiem, Nguyen Xuan | - |
dc.contributor.author | Subedi, Lalita | - |
dc.contributor.author | Oh, Ikhoon | - |
dc.contributor.author | Kim, Ji-Young | - |
dc.contributor.author | Kim, Sun Yeou | - |
dc.contributor.author | Kim, Seung Hyun | - |
dc.date.available | 2020-02-27T07:43:24Z | - |
dc.date.created | 2020-02-04 | - |
dc.date.issued | 2020-09-01 | - |
dc.identifier.issn | 1028-6020 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/2927 | - |
dc.description.abstract | Two previously undescribed limonoids, 1-O-benzoyl-3-O-deactylnimbolinin C (1) and a pair of epimers named toosendalactonins A and B (12a and 12b), together with ten known compounds (2-11) were isolated from the fruits of Melia azedarach L. Their structures were determined by extensive spectroscopic methods, including 1D-, 2D-nuclear magnetic resonance, and mass spectrometry. All the isolated compounds were evaluated for their nitric oxide (NO) inhibition in lipopolysaccharide-activated microglia and nerve growth factor (NGF) production in astrocytes. Compounds 1-2 and 5-8 significantly inhibited NO production, which is comparable to the positive control, L-NMMA. Previously undescribed limonoid, compound 12, and two known limonoids, munronin K (3) and 12-O-methyl-1-O-deacetyl-nimbolinin B (4), showed the highest potency to increase the NGF production in C6 astrocytes. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.relation.isPartOf | JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | - |
dc.title | Isolation of bioactive limonoids from the fruits of Melia azedarach | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000487431600001 | - |
dc.identifier.doi | 10.1080/10286020.2019.1666826 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, v.22, no.9, pp.830 - 838 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85074031336 | - |
dc.citation.endPage | 838 | - |
dc.citation.startPage | 830 | - |
dc.citation.title | JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | - |
dc.citation.volume | 22 | - |
dc.citation.number | 9 | - |
dc.contributor.affiliatedAuthor | Subedi, Lalita | - |
dc.contributor.affiliatedAuthor | Kim, Sun Yeou | - |
dc.type.docType | Article; Early Access | - |
dc.subject.keywordAuthor | Melia azedarach | - |
dc.subject.keywordAuthor | Meliaceae | - |
dc.subject.keywordAuthor | limonoids | - |
dc.subject.keywordAuthor | anti-neuroinflammatory activity | - |
dc.subject.keywordAuthor | neuroprotective activity | - |
dc.subject.keywordPlus | CYTOTOXIC LIMONOIDS | - |
dc.subject.keywordPlus | TETRANORTRITERPENOIDS | - |
dc.subject.keywordPlus | GLYCOSIDES | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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