Isolation of bioactive limonoids from the fruits of Melia azedarach
- Authors
- Park, SeonJu; Nhiem, Nguyen Xuan; Subedi, Lalita; Oh, Ikhoon; Kim, Ji-Young; Kim, Sun Yeou; Kim, Seung Hyun
- Issue Date
- 1-Sep-2020
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- Melia azedarach; Meliaceae; limonoids; anti-neuroinflammatory activity; neuroprotective activity
- Citation
- JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, v.22, no.9, pp.830 - 838
- Journal Title
- JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
- Volume
- 22
- Number
- 9
- Start Page
- 830
- End Page
- 838
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/2927
- DOI
- 10.1080/10286020.2019.1666826
- ISSN
- 1028-6020
- Abstract
- Two previously undescribed limonoids, 1-O-benzoyl-3-O-deactylnimbolinin C (1) and a pair of epimers named toosendalactonins A and B (12a and 12b), together with ten known compounds (2-11) were isolated from the fruits of Melia azedarach L. Their structures were determined by extensive spectroscopic methods, including 1D-, 2D-nuclear magnetic resonance, and mass spectrometry. All the isolated compounds were evaluated for their nitric oxide (NO) inhibition in lipopolysaccharide-activated microglia and nerve growth factor (NGF) production in astrocytes. Compounds 1-2 and 5-8 significantly inhibited NO production, which is comparable to the positive control, L-NMMA. Previously undescribed limonoid, compound 12, and two known limonoids, munronin K (3) and 12-O-methyl-1-O-deacetyl-nimbolinin B (4), showed the highest potency to increase the NGF production in C6 astrocytes.
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