Striatal dopamine transporter changes after glucose loading in humans
DC Field | Value | Language |
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dc.contributor.author | Pak, Kyoungjune | - |
dc.contributor.author | Seo, Seongho | - |
dc.contributor.author | Kim, Keunyoung | - |
dc.contributor.author | Lee, Myung Jun | - |
dc.contributor.author | Shin, Myung Jun | - |
dc.contributor.author | Suh, Sunghwan | - |
dc.contributor.author | Im, Hyung-Jun | - |
dc.contributor.author | Park, Jung-Jun | - |
dc.contributor.author | Kim, Seong-Jang | - |
dc.contributor.author | Kim, In Joo | - |
dc.date.available | 2020-02-27T08:40:44Z | - |
dc.date.created | 2020-02-04 | - |
dc.date.issued | 2020-01 | - |
dc.identifier.issn | 1462-8902 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/2932 | - |
dc.description.abstract | Aims The dopamine transporter (DAT) actively translocates dopamine that is released from the presynaptic neurons across the membranes of nerve terminals into the extracellular space. We hypothesized that glucose loading-induced changes in striatal DAT levels could be associated with food intake in humans. Materials and methods An intravenous bolus injection of F-18-FP-CIT was administered after infusion of glucose or placebo (normal saline), and emission data were acquired over 90 minutes in 33 healthy males. For a volume-of-interest-based analysis, an atlas involving sub-striatal regions of ventral striatum (VST), caudate nucleus and putamen was applied. DAT availability and binding potential (BPND) were measured using a simplified reference tissue method with cerebellum as the reference. Results The glucose-loaded BPND from the VST negatively correlated with body mass index (BMI), whereas the placebo-loaded BPND from the VST did not. After loading with glucose, there were substantial increases in BP(ND)s: 18.3%, 71.7% and 34.0% on average in the VST, caudate nucleus and putamen, respectively. Conclusion Striatal DAT changes after glucose loading, and BMI is associated with glucose-loaded DAT availability, not with placebo-loaded DAT availability. DAT might have a role in the reward system of eating behavior. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.relation.isPartOf | DIABETES OBESITY & METABOLISM | - |
dc.title | Striatal dopamine transporter changes after glucose loading in humans | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000488646600001 | - |
dc.identifier.doi | 10.1111/dom.13872 | - |
dc.identifier.bibliographicCitation | DIABETES OBESITY & METABOLISM, v.22, no.1, pp.116 - 122 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85073969527 | - |
dc.citation.endPage | 122 | - |
dc.citation.startPage | 116 | - |
dc.citation.title | DIABETES OBESITY & METABOLISM | - |
dc.citation.volume | 22 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Seo, Seongho | - |
dc.type.docType | Article; Early Access | - |
dc.subject.keywordAuthor | dopamine plasma membrane transport proteins | - |
dc.subject.keywordAuthor | glucose | - |
dc.subject.keywordAuthor | obesity | - |
dc.subject.keywordAuthor | reward | - |
dc.subject.keywordPlus | BODY-MASS INDEX | - |
dc.subject.keywordPlus | RECEPTOR AVAILABILITY | - |
dc.subject.keywordPlus | HEALTHY-VOLUNTEERS | - |
dc.subject.keywordPlus | DORSAL STRIATUM | - |
dc.subject.keywordPlus | BRAIN DOPAMINE | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordPlus | SENSITIVITY | - |
dc.subject.keywordPlus | HORMONES | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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