Striatal dopamine transporter changes after glucose loading in humans
- Authors
- Pak, Kyoungjune; Seo, Seongho; Kim, Keunyoung; Lee, Myung Jun; Shin, Myung Jun; Suh, Sunghwan; Im, Hyung-Jun; Park, Jung-Jun; Kim, Seong-Jang; Kim, In Joo
- Issue Date
- Jan-2020
- Publisher
- WILEY
- Keywords
- dopamine plasma membrane transport proteins; glucose; obesity; reward
- Citation
- DIABETES OBESITY & METABOLISM, v.22, no.1, pp.116 - 122
- Journal Title
- DIABETES OBESITY & METABOLISM
- Volume
- 22
- Number
- 1
- Start Page
- 116
- End Page
- 122
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/2932
- DOI
- 10.1111/dom.13872
- ISSN
- 1462-8902
- Abstract
- Aims The dopamine transporter (DAT) actively translocates dopamine that is released from the presynaptic neurons across the membranes of nerve terminals into the extracellular space. We hypothesized that glucose loading-induced changes in striatal DAT levels could be associated with food intake in humans. Materials and methods An intravenous bolus injection of F-18-FP-CIT was administered after infusion of glucose or placebo (normal saline), and emission data were acquired over 90 minutes in 33 healthy males. For a volume-of-interest-based analysis, an atlas involving sub-striatal regions of ventral striatum (VST), caudate nucleus and putamen was applied. DAT availability and binding potential (BPND) were measured using a simplified reference tissue method with cerebellum as the reference. Results The glucose-loaded BPND from the VST negatively correlated with body mass index (BMI), whereas the placebo-loaded BPND from the VST did not. After loading with glucose, there were substantial increases in BP(ND)s: 18.3%, 71.7% and 34.0% on average in the VST, caudate nucleus and putamen, respectively. Conclusion Striatal DAT changes after glucose loading, and BMI is associated with glucose-loaded DAT availability, not with placebo-loaded DAT availability. DAT might have a role in the reward system of eating behavior.
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