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Isolation of indole alkaloid and anthranilic acid derivatives from Indigo Pulverata Levis

Authors
Park, Kyoung JinKim, Dong HyunKim, Chung SubOh, JoonseokSubedi, LalitaSon, Mi WonChoi, Sang ZinKim, Sun YeouLee, Kang Ro
Issue Date
12-Dec-2018
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Keywords
Indigo Pulverata Levis; Indole alkaloid; Anthranilic acid; DP4; Neuroprotection
Citation
TETRAHEDRON LETTERS, v.59, no.50, pp.4380 - 4383
Journal Title
TETRAHEDRON LETTERS
Volume
59
Number
50
Start Page
4380
End Page
4383
URI
https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/2974
DOI
10.1016/j.tetlet.2018.10.057
ISSN
0040-4039
Abstract
A new indole alkaloid, pulveratinol (1), and two new anthranilic acid derivatives (2 and 3) were isolated from Indigo Pulverata Levis, together with 12 known compounds (4-15). The structures of the new compounds (1-3) were determined through spectroscopic methods. The absolute configuration of 1 was confirmed further by electronic circular dichroism (ECD) data analysis and computational method with advanced statistics (DP4). All isolated compounds (1-15) were evaluated for their potential neuroprotective effects through induction of nerve growth factor (NGF) in C6 glioma cells. (C) 2018 Published by Elsevier Ltd.
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