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Isolation of indole alkaloid and anthranilic acid derivatives from Indigo Pulverata Levis
- Authors
- Park, Kyoung Jin; Kim, Dong Hyun; Kim, Chung Sub; Oh, Joonseok; Subedi, Lalita; Son, Mi Won; Choi, Sang Zin; Kim, Sun Yeou; Lee, Kang Ro
- Issue Date
- 12-Dec-2018
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Indigo Pulverata Levis; Indole alkaloid; Anthranilic acid; DP4; Neuroprotection
- Citation
- TETRAHEDRON LETTERS, v.59, no.50, pp.4380 - 4383
- Journal Title
- TETRAHEDRON LETTERS
- Volume
- 59
- Number
- 50
- Start Page
- 4380
- End Page
- 4383
- ISSN
- 0040-4039
- Abstract
- A new indole alkaloid, pulveratinol (1), and two new anthranilic acid derivatives (2 and 3) were isolated from Indigo Pulverata Levis, together with 12 known compounds (4-15). The structures of the new compounds (1-3) were determined through spectroscopic methods. The absolute configuration of 1 was confirmed further by electronic circular dichroism (ECD) data analysis and computational method with advanced statistics (DP4). All isolated compounds (1-15) were evaluated for their potential neuroprotective effects through induction of nerve growth factor (NGF) in C6 glioma cells. (C) 2018 Published by Elsevier Ltd.
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Related Researcher
- Kim, Sun Yeou
- Pharmacy (Dept.of Pharmacy)