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Association of a genetic polymorphism of IL1RN with risk of acute pancreatitis in a Korean ethnic group

Authors
Park, Jin WooChoi, Ja SungHan, Ki JoonLee, Sang HeunKim, Eui JooCho, Jae Hee
Issue Date
Nov-2018
Publisher
KOREAN ASSOC INTERNAL MEDICINE
Keywords
Pancreatitis; Polymorphism; single nucleotide; Interleukins; Tumor necrosis factor-alpha
Citation
KOREAN JOURNAL OF INTERNAL MEDICINE, v.33, no.6, pp.1103 - 1110
Journal Title
KOREAN JOURNAL OF INTERNAL MEDICINE
Volume
33
Number
6
Start Page
1103
End Page
1110
URI
https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/3142
DOI
10.3904/kjim.2017.133
ISSN
1226-3303
Abstract
Background/Aims: Several epidemiological studies have validated the association of interleukin gene polymorphisms with acute pancreatitis (AP) in different populations. However, there have been few studies in Asian ethnic groups. We aimed to investigate the relationships between inflammatory cytokine polymorphisms and AP as pilot research in a Korean ethnic group. Methods: Patients who had been diagnosed with AP were prospectively enrolled. DNA was extracted from whole blood, and DNA sequencing was subsequently performed. Single-nucleotide polymorphisms (SNPs) of the interleukin 1 beta (IL1B), interleukin 1 receptor antagonist (IL1RN), and tumor necrosis factor alpha (TNFA) genes of patients with AP were compared to those of normal controls. Results: Between January 2011 and January 2013, a total of 65 subjects were enrolled (40 patients with AP vs. 25 healthy controls). One intronic SNP (IL1RN -1129T>C, rs4251961) was significantly associated with the risk of AP (odds ratio, 0.304; 95% confidence interval, 0.095 to 0.967; p = 0.043). However, in our study, AP was not found to be associated with polymorphisms in the promoter regions of inflammatory cytokine genes, including IL1B (-118C>T, c47+242C>T, +3954C/T, and -598T>C) and TNFA (-1211T>C, -1043C>A, -1037C>T, -488G>A, and -418G>A). Conclusions: IL1RN -1129T>C (rs4251961) genotypes might be associated with a significant increase of AP risk in a Korean ethnic group.
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