Biological Evaluation of a New Lignan from the Roots of Rice (Oryza sativa)
DC Field | Value | Language |
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dc.contributor.author | Lee, Tae Kyoung | - |
dc.contributor.author | Lee, Dahae | - |
dc.contributor.author | Yu, Jae Sik | - |
dc.contributor.author | Jo, Mun Seok | - |
dc.contributor.author | Baek, Su Cheol | - |
dc.contributor.author | Shin, Myoung-Sook | - |
dc.contributor.author | Ko, Yoon-Joo | - |
dc.contributor.author | Kang, Ki Sung | - |
dc.contributor.author | Kim, Ki Hyun | - |
dc.date.available | 2020-02-27T08:42:43Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2018-11 | - |
dc.identifier.issn | 1612-1872 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/3164 | - |
dc.description.abstract | LC/MS-based phytochemical analysis of an EtOH extract of the roots of rice (Oryza sativa; Gramineae), which takes a crucial role in the stable crop population in Asia, resulted in the isolation of a new lignan, oryzativol C (1), as a minor component. The chemical structure of compound 1 was unambiguously confirmed using spectroscopic evidence (including 1D- and 2D-NMR data), HR-ESI-MS, and CD data analysis. Considering the traditional medicinal efficacy of O. sativa and its importance as a food crop, compound 1 was evaluated for effects on breast cancer cell lines (MDA-MB-231) and on glucose-stimulated insulin secretion in an INS-1 pancreatic beta-cell line. Compound 1 showed mild cytotoxicity toward the MDA-MB-231. Furthermore, compound 1 stimulated insulin secretion in INS-1 pancreatic beta-cells without inducing cytotoxicity. These results indicate that compound 1 is an active ingredient of O. sativa that offers health benefits including inhibition of breast cancer cell proliferation and hyperglycemia control. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.relation.isPartOf | CHEMISTRY & BIODIVERSITY | - |
dc.subject | IDENTIFICATION | - |
dc.subject | CONSTITUENTS | - |
dc.subject | PHYTOALEXIN | - |
dc.subject | SEEDS | - |
dc.title | Biological Evaluation of a New Lignan from the Roots of Rice (Oryza sativa) | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000451009300010 | - |
dc.identifier.doi | 10.1002/cbdv.201800333 | - |
dc.identifier.bibliographicCitation | CHEMISTRY & BIODIVERSITY, v.15, no.11 | - |
dc.identifier.scopusid | 2-s2.0-85055556006 | - |
dc.citation.title | CHEMISTRY & BIODIVERSITY | - |
dc.citation.volume | 15 | - |
dc.citation.number | 11 | - |
dc.contributor.affiliatedAuthor | Shin, Myoung-Sook | - |
dc.contributor.affiliatedAuthor | Kang, Ki Sung | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Oryza sativa | - |
dc.subject.keywordAuthor | Gramineae | - |
dc.subject.keywordAuthor | lignan | - |
dc.subject.keywordAuthor | glucose-stimulated insulin secretion | - |
dc.subject.keywordAuthor | cytotoxicity | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | CONSTITUENTS | - |
dc.subject.keywordPlus | PHYTOALEXIN | - |
dc.subject.keywordPlus | SEEDS | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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