Biological Evaluation of a New Lignan from the Roots of Rice (Oryza sativa)
- Authors
- Lee, Tae Kyoung; Lee, Dahae; Yu, Jae Sik; Jo, Mun Seok; Baek, Su Cheol; Shin, Myoung-Sook; Ko, Yoon-Joo; Kang, Ki Sung; Kim, Ki Hyun
- Issue Date
- Nov-2018
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- Oryza sativa; Gramineae; lignan; glucose-stimulated insulin secretion; cytotoxicity
- Citation
- CHEMISTRY & BIODIVERSITY, v.15, no.11
- Journal Title
- CHEMISTRY & BIODIVERSITY
- Volume
- 15
- Number
- 11
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/3164
- DOI
- 10.1002/cbdv.201800333
- ISSN
- 1612-1872
- Abstract
- LC/MS-based phytochemical analysis of an EtOH extract of the roots of rice (Oryza sativa; Gramineae), which takes a crucial role in the stable crop population in Asia, resulted in the isolation of a new lignan, oryzativol C (1), as a minor component. The chemical structure of compound 1 was unambiguously confirmed using spectroscopic evidence (including 1D- and 2D-NMR data), HR-ESI-MS, and CD data analysis. Considering the traditional medicinal efficacy of O. sativa and its importance as a food crop, compound 1 was evaluated for effects on breast cancer cell lines (MDA-MB-231) and on glucose-stimulated insulin secretion in an INS-1 pancreatic beta-cell line. Compound 1 showed mild cytotoxicity toward the MDA-MB-231. Furthermore, compound 1 stimulated insulin secretion in INS-1 pancreatic beta-cells without inducing cytotoxicity. These results indicate that compound 1 is an active ingredient of O. sativa that offers health benefits including inhibition of breast cancer cell proliferation and hyperglycemia control.
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