Virus-mimetic polymer nanoparticles displaying hemagglutinin as an adjuvant-free influenza vaccine
- Authors
- Lee, Chaeyeon; Jeong, Jonghwa; Lee, Taeheon; Zhang, Wei; Xu, Li; Choi, Ji Eun; Park, Ji Hyun; Song, Jae Kwang; Jang, Sinae; Eom, Chi-Yong; Shim, KyuHwan; An, Seong Soo A.; Kang, Young-Sun; Kwak, Minseok; Jeon, Hyeong Jin; Go, Jeung Sang; Suh, Yung Doug; Jin, Jun-O; Paik, Hyun-jong
- Issue Date
- Nov-2018
- Publisher
- ELSEVIER SCI LTD
- Keywords
- in situ method; Protein-polymer nanoparticle; Virus-mimicking; Antigen-specific immune activation; Influenza vaccine
- Citation
- BIOMATERIALS, v.183, pp.234 - 242
- Journal Title
- BIOMATERIALS
- Volume
- 183
- Start Page
- 234
- End Page
- 242
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/3169
- DOI
- 10.1016/j.biomaterials.2018.08.036
- ISSN
- 0142-9612
- Abstract
- The generation of virus-mimetic nanoparticles has received much attention in developing a new vaccine for overcoming the limitations of current vaccines. Thus, a method, encompassing most viral features for their size, hydrophobic domain and antigen display, would represent a meaningful direction for the vaccine development. In the present study, a polymer-templated protein nanoball with direction oriented hemagglutininl on its surface (H1-NB) was prepared as a new influenza vaccine, exhibiting most of the viral features. Moreover, the concentrations of antigen on the particle surface were controlled, and its effect on immunogenicity was estimated by in vivo studies. Finally, H1-NB efficiently promoted H1-specific immune activation and cross-protective activities, which consequently prevented H1N1 infections in mice.
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Collections - 바이오나노대학 > 바이오나노학과 > 1. Journal Articles
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