The memory-enhancing effects of 7,8,4 '-trihydroxyisoflavone, a major metabolite of daidzein, are associated with activation of the cholinergic system and BDNF signaling pathway in mice
DC Field | Value | Language |
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dc.contributor.author | Ko, Yong-Hyun | - |
dc.contributor.author | Kwon, Seung-Hwan | - |
dc.contributor.author | Ma, Shi-Xun | - |
dc.contributor.author | Seo, Jee-Yeon | - |
dc.contributor.author | Lee, Bo-Ram | - |
dc.contributor.author | Kim, Kyungin | - |
dc.contributor.author | Kim, Sun Yeou | - |
dc.contributor.author | Lee, Seok-Yong | - |
dc.contributor.author | Jang, Choon-Gon | - |
dc.date.available | 2020-02-27T09:41:59Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2018-09 | - |
dc.identifier.issn | 0361-9230 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/3402 | - |
dc.description.abstract | Daidzein is one of the dietary isoflavones present in soybean-based products. After ingestion, daidzein is bioconverted into its major metabolite, 7,8,4'-trihydroxyisoflavone (THIF). Given the pharmacological importance of daidzein, 7,8,4'-THIF has also attracted the interest of researchers. However, there are no reports on the effects of 7,8,4'-THIF on cognition and memory with regard to the cholinergic system. Therefore, this study sought to evaluate the memory-enhancing effects of 7,8,4'-THIF in mice. Treatment with 7,8,4'-THIF ameliorated the cognitive impairments induced by scopolamine, a muscarinic acetylcholine receptor antagonist, in the Y-maze and passive avoidance tests. Interestingly, 7,8,4'-THIF treatment also improved cognitive function in normal mice. This treatment was also able to reverse acetylcholinesterase (AChE) and thiobarbituric acid reactive substance (TBARS) activities in the hippocampus. Finally, 7,8,4'-THIF significantly increased the expression levels of the following molecules in the hippocampus: brain-derived neurotrophic factor (BDNF); phospho extracellular signal-regulated kinase (ERK); phospho cAMP response element binding (CREB); and choline acetyltransferase (ChAT). Our data suggest that 7,8,4'-THIF, a metabolized product of daidzein, improves cognitive function by activating the cholinergic system and the BDNF/ERK/CREB signaling pathway in mice. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.relation.isPartOf | BRAIN RESEARCH BULLETIN | - |
dc.subject | SCOPOLAMINE-INDUCED AMNESIA | - |
dc.subject | ELEMENT-BINDING PROTEIN | - |
dc.subject | LONG-TERM POTENTIATION | - |
dc.subject | COGNITIVE IMPAIRMENT | - |
dc.subject | NEUROTROPHIC FACTOR | - |
dc.subject | ALZHEIMERS-DISEASE | - |
dc.subject | SOY ISOFLAVONES | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | NMDA RECEPTORS | - |
dc.subject | SPATIAL MEMORY | - |
dc.title | The memory-enhancing effects of 7,8,4 '-trihydroxyisoflavone, a major metabolite of daidzein, are associated with activation of the cholinergic system and BDNF signaling pathway in mice | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000448223400022 | - |
dc.identifier.doi | 10.1016/j.brainresbull.2018.07.012 | - |
dc.identifier.bibliographicCitation | BRAIN RESEARCH BULLETIN, v.142, pp.197 - 206 | - |
dc.identifier.scopusid | 2-s2.0-85050505249 | - |
dc.citation.endPage | 206 | - |
dc.citation.startPage | 197 | - |
dc.citation.title | BRAIN RESEARCH BULLETIN | - |
dc.citation.volume | 142 | - |
dc.contributor.affiliatedAuthor | Kim, Sun Yeou | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | 7,8,4 &apos | - |
dc.subject.keywordAuthor | -Trihydrozyisoflavone | - |
dc.subject.keywordAuthor | Cognition | - |
dc.subject.keywordAuthor | Cholinergic system | - |
dc.subject.keywordAuthor | Brain-derived neurotrophic factor | - |
dc.subject.keywordAuthor | Alzheimer&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordPlus | SCOPOLAMINE-INDUCED AMNESIA | - |
dc.subject.keywordPlus | ELEMENT-BINDING PROTEIN | - |
dc.subject.keywordPlus | LONG-TERM POTENTIATION | - |
dc.subject.keywordPlus | COGNITIVE IMPAIRMENT | - |
dc.subject.keywordPlus | NEUROTROPHIC FACTOR | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | SOY ISOFLAVONES | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | NMDA RECEPTORS | - |
dc.subject.keywordPlus | SPATIAL MEMORY | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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