The memory-enhancing effects of 7,8,4 '-trihydroxyisoflavone, a major metabolite of daidzein, are associated with activation of the cholinergic system and BDNF signaling pathway in mice
- Authors
- Ko, Yong-Hyun; Kwon, Seung-Hwan; Ma, Shi-Xun; Seo, Jee-Yeon; Lee, Bo-Ram; Kim, Kyungin; Kim, Sun Yeou; Lee, Seok-Yong; Jang, Choon-Gon
- Issue Date
- Sep-2018
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- 7,8,4 ' -Trihydrozyisoflavone; Cognition; Cholinergic system; Brain-derived neurotrophic factor; Alzheimer' s disease
- Citation
- BRAIN RESEARCH BULLETIN, v.142, pp.197 - 206
- Journal Title
- BRAIN RESEARCH BULLETIN
- Volume
- 142
- Start Page
- 197
- End Page
- 206
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/3402
- DOI
- 10.1016/j.brainresbull.2018.07.012
- ISSN
- 0361-9230
- Abstract
- Daidzein is one of the dietary isoflavones present in soybean-based products. After ingestion, daidzein is bioconverted into its major metabolite, 7,8,4'-trihydroxyisoflavone (THIF). Given the pharmacological importance of daidzein, 7,8,4'-THIF has also attracted the interest of researchers. However, there are no reports on the effects of 7,8,4'-THIF on cognition and memory with regard to the cholinergic system. Therefore, this study sought to evaluate the memory-enhancing effects of 7,8,4'-THIF in mice. Treatment with 7,8,4'-THIF ameliorated the cognitive impairments induced by scopolamine, a muscarinic acetylcholine receptor antagonist, in the Y-maze and passive avoidance tests. Interestingly, 7,8,4'-THIF treatment also improved cognitive function in normal mice. This treatment was also able to reverse acetylcholinesterase (AChE) and thiobarbituric acid reactive substance (TBARS) activities in the hippocampus. Finally, 7,8,4'-THIF significantly increased the expression levels of the following molecules in the hippocampus: brain-derived neurotrophic factor (BDNF); phospho extracellular signal-regulated kinase (ERK); phospho cAMP response element binding (CREB); and choline acetyltransferase (ChAT). Our data suggest that 7,8,4'-THIF, a metabolized product of daidzein, improves cognitive function by activating the cholinergic system and the BDNF/ERK/CREB signaling pathway in mice.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 약학대학 > 약학과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/3402)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.