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Cited 9 time in webofscience Cited 10 time in scopus
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7 Tesla magnetic resonance imaging of caudal anterior cingulate and posterior cingulate cortex atrophy in patients with trigeminal neuralgia

Authors
Moon, Hyeong CheolPark, Chan-AJeon, Yeong-JaeYou, Soon TaeBaek, Hyun ManLee, Youn JooCho, Chul BeomCheong, Chae JoonPark, Young Seok
Issue Date
Sep-2018
Publisher
ELSEVIER SCIENCE INC
Keywords
7 Tesla MRI; Trigeminal neuralgia; Gray matter
Citation
MAGNETIC RESONANCE IMAGING, v.51, pp.144 - 150
Journal Title
MAGNETIC RESONANCE IMAGING
Volume
51
Start Page
144
End Page
150
URI
https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/3412
DOI
10.1016/j.mri.2018.05.005
ISSN
0730-725X
Abstract
The cingulate cortex (CC) is a brain region that plays a key role in pain processing, but CC abnormalities are not unclear in patients with trigeminal neuralgia (TN). The purpose of this study was to determine the central causal mechanisms of TN and the surrounding brain structure in healthy controls and patients with TN using 7 Tesla (T) magnetic resonance imaging (MRI). Whole-brain parcellation in gray matter volume and thickness was assessed in 15 patients with TN and 16 healthy controls matched for sex, age, and regional variability using T1-weighted imaging. Regions of interest (ROIs) were measured in rostral anterior CC (rACC), caudal anterior CC (cACC) and posterior CC (PCC). We also investigated associations between gray matter volume or thickness and clinical symptoms, such as pain duration, Barrow Neurologic Institute (BNI) scores, offender vessel, and medications, in patients with TN. The cACC and PCC exhibited gray matter atrophy and reduced thickness between the TN and control groups. However, the rACC did not. Cortical volumes were negatively correlated with pain duration in transverse and inferior temporal areas, and thickness was also negatively correlated with pain duration in superior frontal and parietal areas. The cACC and PCC gray matter atrophy occurred in the patients with TN, and pain duration was associated with frontal, parietal, and temporal cortical regions. These results suggest that the cACC, PCC but not the rACC are associated with central pain mechanisms in TN.
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