Computed tomography characteristics of lung adenocarcinomas with epidermal growth factor receptor mutation: A propensity score matching study
- Authors
- Suh, Young Joo; Lee, Hyun-Ju; Kim, Young Jae; Kim, Kwang Gi; Kim, Heekyung; Jeon, Yoon Kyung; Kim, Young Tae
- Issue Date
- Sep-2018
- Publisher
- ELSEVIER IRELAND LTD
- Keywords
- Lung adenocarcinoma; EGFR mutation; Computed tomography
- Citation
- LUNG CANCER, v.123, pp.52 - 59
- Journal Title
- LUNG CANCER
- Volume
- 123
- Start Page
- 52
- End Page
- 59
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/3413
- DOI
- 10.1016/j.lungcan.2018.06.030
- ISSN
- 0169-5002
- Abstract
- Objectives: We investigated the relationship between computed tomography (CT) characteristics and epidermal growth factor receptor (EGFR) mutations in a large Asian cohort who received surgical resection of invasive lung adenocarcinoma. Materials and Methods: We retrospectively included 864 patients (524 with EGFR mutation and 340 with EGFR wild-type) who received surgical resections for invasive lung adenocarcinomas. After applying propensity score matching, 312 patients with mutated EGFR were matched with 312 patients with wild-type EGFR. CT characteristics, predominant histologic subtype, and CT measurement parameters (volume and estimated diameter of the total tumor and inner solid portion and ground-glass opacity [GGO] proportion) were compared within matched pairs. Results: Tumors in the EGFR mutation group showed higher proportions of pure ground-glass nodules (4.1% vs 1.3%), GGO-predominant (23.7% vs 14.7%), and solid-predominant part-solid nodules (37.2% vs 31.7%) CT characteristics, whereas EGFR wild-type tumors predominantly presented as pure solid nodules (34.6% vs 52.2%, P < 0.0001). EGFR mutation tumors more frequently had a lepidic-predominant subtype than did EGFR wild-type tumors (20.2% and 11.9%; P < 0.0001), and showed a smaller whole tumor size and solid portion (P < 0.0001) with a higher GGO proportion (P < 0.0001). Tumors with exon 21 missense mutations showed the highest GGO proportion and the smallest inner solid portion size, followed by tumors harboring an exon 19 deletion, compared with EGFR wild-type tumors (posthoc P < 0.01). Conclusion: Adenocarcinomas with EGFR mutations had a higher GGO proportion than those with wild-type EGFR after matching of clinical variables. Lesions with an exon 21 mutation had a higher GGO proportion than lesions with other mutations.
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