Impact of plasma oxidation on structural features of human epidermal growth factor
DC Field | Value | Language |
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dc.contributor.author | Yusupov, Maksudbek | - |
dc.contributor.author | Lackmann, Jan-Wilm | - |
dc.contributor.author | Razzokov, Jamoliddin | - |
dc.contributor.author | Kumar, Surendra | - |
dc.contributor.author | Stapelmann, Katharina | - |
dc.contributor.author | Bogaerts, Annemie | - |
dc.date.available | 2020-02-27T09:42:44Z | - |
dc.date.created | 2020-02-07 | - |
dc.date.issued | 2018-08 | - |
dc.identifier.issn | 1612-8850 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/3506 | - |
dc.description.abstract | We perform computer simulations supported by experiments to investigate the oxidation of an important signaling protein, that is, human epidermal growth factor (hEGF), caused by cold atmospheric plasma (CAP) treatment. Specifically, we study the conformational changes of hEGF with different degrees of oxidation, to mimic short and long CAP treatment times. Our results indicate that the oxidized structures become more flexible, due to their conformational changes and breakage of the disulfide bonds, especially at higher oxidation degrees. MM/GBSA calculations reveal that an increasing oxidation level leads to a lower binding free energy of hEGF with its receptor. These results help to understand the fundamentals of the use of CAP for wound healing versus cancer treatment at short and longer treatment times. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.relation.isPartOf | PLASMA PROCESSES AND POLYMERS | - |
dc.subject | ATMOSPHERIC-PRESSURE PLASMA | - |
dc.subject | ARGON PLASMA | - |
dc.subject | HUMAN KERATINOCYTES | - |
dc.subject | CRYSTAL-STRUCTURE | - |
dc.subject | CHRONIC WOUNDS | - |
dc.subject | CELL-DEATH | - |
dc.subject | DYNAMICS | - |
dc.subject | FIELD | - |
dc.title | Impact of plasma oxidation on structural features of human epidermal growth factor | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000441895700004 | - |
dc.identifier.doi | 10.1002/ppap.201800022 | - |
dc.identifier.bibliographicCitation | PLASMA PROCESSES AND POLYMERS, v.15, no.8 | - |
dc.identifier.scopusid | 2-s2.0-85046531615 | - |
dc.citation.title | PLASMA PROCESSES AND POLYMERS | - |
dc.citation.volume | 15 | - |
dc.citation.number | 8 | - |
dc.contributor.affiliatedAuthor | Kumar, Surendra | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | cold atmospheric plasma | - |
dc.subject.keywordAuthor | molecular dynamics | - |
dc.subject.keywordAuthor | plasma treatment | - |
dc.subject.keywordAuthor | protein oxidation | - |
dc.subject.keywordPlus | ATMOSPHERIC-PRESSURE PLASMA | - |
dc.subject.keywordPlus | ARGON PLASMA | - |
dc.subject.keywordPlus | HUMAN KERATINOCYTES | - |
dc.subject.keywordPlus | CRYSTAL-STRUCTURE | - |
dc.subject.keywordPlus | CHRONIC WOUNDS | - |
dc.subject.keywordPlus | CELL-DEATH | - |
dc.subject.keywordPlus | DYNAMICS | - |
dc.subject.keywordPlus | FIELD | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalResearchArea | Polymer Science | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.relation.journalWebOfScienceCategory | Physics, Fluids & Plasmas | - |
dc.relation.journalWebOfScienceCategory | Physics, Condensed Matter | - |
dc.relation.journalWebOfScienceCategory | Polymer Science | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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