Impact of plasma oxidation on structural features of human epidermal growth factor
- Authors
- Yusupov, Maksudbek; Lackmann, Jan-Wilm; Razzokov, Jamoliddin; Kumar, Surendra; Stapelmann, Katharina; Bogaerts, Annemie
- Issue Date
- Aug-2018
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- cold atmospheric plasma; molecular dynamics; plasma treatment; protein oxidation
- Citation
- PLASMA PROCESSES AND POLYMERS, v.15, no.8
- Journal Title
- PLASMA PROCESSES AND POLYMERS
- Volume
- 15
- Number
- 8
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/3506
- DOI
- 10.1002/ppap.201800022
- ISSN
- 1612-8850
- Abstract
- We perform computer simulations supported by experiments to investigate the oxidation of an important signaling protein, that is, human epidermal growth factor (hEGF), caused by cold atmospheric plasma (CAP) treatment. Specifically, we study the conformational changes of hEGF with different degrees of oxidation, to mimic short and long CAP treatment times. Our results indicate that the oxidized structures become more flexible, due to their conformational changes and breakage of the disulfide bonds, especially at higher oxidation degrees. MM/GBSA calculations reveal that an increasing oxidation level leads to a lower binding free energy of hEGF with its receptor. These results help to understand the fundamentals of the use of CAP for wound healing versus cancer treatment at short and longer treatment times.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - ETC > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/3506)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.