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Clinical characteristics and outcomes of patients with chronic disseminated candidiasis who need adjuvant corticosteroid therapy
- Authors
- Jang, Young-Rock; Kim, Min-Chul; Kim, Taeeun; Chong, Yong Pil; Lee, Sang-Oh; Choi, Sang-Ho; Kim, Yang Soo; Woo, Jun Hee; Hong, Jung Yong; Yoon, Dok Hyun; Suh, Cheolwon; Lee, Jung-Hee; Lee, Je-Hwan; Lee, Kyoo-Hyung; Kim, Sung-Han
- Issue Date
- Aug-2018
- Publisher
- OXFORD UNIV PRESS
- Keywords
- candidiasis; adrenal cortex hormones; leukemia; liver abscess; immune recostitution inflammatory syndrome
- Citation
- MEDICAL MYCOLOGY, v.56, no.6, pp.782 - 786
- Journal Title
- MEDICAL MYCOLOGY
- Volume
- 56
- Number
- 6
- Start Page
- 782
- End Page
- 786
- ISSN
- 1369-3786
- Abstract
- We performed a retrospective study involving 21 patients with chronic disseminate candidiasis (CDC) and 38 patients with candidemia. Neutropenia of >2 weeks' duration was more common in those with CDC (71%) than in those with candidemia (26%, P < .001), and the azole-resistant rate in patients with CDC (5%) was lower than that in those with candidemia (29%, P = .03). Of the 21 patients with CDC, five (24%) needed adjuvant corticosteroid therapy due to persistent debilitating fever (median, 19 days). Rapid defervescence (median, 5 days) occurred after adjuvant corticosteroid therapy. However, there were no significant differences in 90-day mortality between CDC patients with and without corticosteroid therapy. Further prospective data are needed to define the role of steroids in this setting.
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