Structural Characterization of Terpenoids from Abies holophylla Using Computational and Statistical Methods and Their Biological Activities
- Authors
- Kim, Chung Sub; Oh, Joonseok; Subedi, Lalita; Kim, Sun Yeou; Choi, Sang Un; Lee, Kang Ro
- Issue Date
- Aug-2018
- Publisher
- AMER CHEMICAL SOC
- Citation
- JOURNAL OF NATURAL PRODUCTS, v.81, no.8, pp.1795 - 1802
- Journal Title
- JOURNAL OF NATURAL PRODUCTS
- Volume
- 81
- Number
- 8
- Start Page
- 1795
- End Page
- 1802
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/3536
- DOI
- 10.1021/acs.jnatprod.8b00245
- ISSN
- 0163-3864
- Abstract
- Three new diterpenoids (1-3) and three new triterpenoids (4-6) were isolated from the trunk of Abies holophylla together with 19 known terpenoids. The chemical structures of 1-6 were determined through NMR and MS data analyses. Also, the structural assignments of some of these compounds were verified and elucidated utilizing computational methods coupled with a statistical procedure (CP3, DP4, and DP4+). All the isolated compounds were evaluated for their cytotoxicity against four human cancer cell lines (A549, SK-OV-3, SK-MEL-2, and HCT-15). In addition, the compounds were tested for their anti-inflammatory effects in lipopolysaccharide-stimulated murine microglia BV2 cells by measuring nitric oxide levels, and for their neuroprotective activity in C6 cells through induction of nerve growth factor.
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Collections - 약학대학 > 약학과 > 1. Journal Articles
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