Phytochemicals: Target-Based Therapeutic Strategies for Diabetic Retinopathy
- Authors
- Parveen, Amna; Kim, Jin Hyun; Oh, Byeong Gyu; Subedi, Lalita; Khan, Zahra; Kim, Sun Yeou
- Issue Date
- Jul-2018
- Publisher
- MDPI
- Keywords
- diabetic retinopathy; protein kinase C; advanced glycation end-products; phytochemicals; oxidative stress; mitogen-activated protein kinases; vascular endothelial growth factor; poly (ADP-ribose) polymerase; metalloproteinase-9; reactive oxygen species; aldose reductase
- Citation
- MOLECULES, v.23, no.7
- Journal Title
- MOLECULES
- Volume
- 23
- Number
- 7
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/3611
- DOI
- 10.3390/molecules23071519
- ISSN
- 1420-3049
- Abstract
- Background: A variety of causative factors are involved in the initiation of diabetic retinopathy (DR). Current antidiabetic therapies are expensive and not easily accessible by the public. Furthermore, the use of multiple synthetic drugs leads to severe side effects, which worsen the diabetic patient's condition. Medicinal plants and their derived phytochemicals are considered safe and effective treatment and their consumption can reduce the DR risk. In this article, we discuss a variety of medicinal plants, and their noteworthy bio-active constituents, that will be utilized as target based therapeutic strategies for DR. Methods: A broad-spectrum study was conducted using published English works in various electronic databases including Science Direct, PubMed, Scopus, and Google Scholar. Results: Targeting the multiple pathological factors including ROS, AGEs formation, hexosamine flux, PARP, PKC, and MAPK activation through variety of bioactive constituents in medicinal plants, diabetes progression can be delayed with improved loss of vision. Conclusions: Data reveals that traditional herbs and their prominent bioactive components control and normalize pathological cellular factors involved in DR progression. Therefore, studies should be carried out to explore the protective retinopathy effects of medicinal plants using experimental animal and humans models.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 약학대학 > 약학과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/3611)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.