Association between involuntary weight loss with low muscle mass and health-related quality of life in community-dwelling older adults: Nationwide surveys (KNHANES 2008-2011)
- Authors
- Kim, Miji; Kim, Junghoon; Won, Chang Won
- Issue Date
- Jun-2018
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Weight loss; Muscle mass; Body composition; Aging; Quality of life
- Citation
- EXPERIMENTAL GERONTOLOGY, v.106, pp.39 - 45
- Journal Title
- EXPERIMENTAL GERONTOLOGY
- Volume
- 106
- Start Page
- 39
- End Page
- 45
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/3671
- DOI
- 10.1016/j.exger.2018.02.027
- ISSN
- 0531-5565
- Abstract
- Objectives: To investigate the relationship between involuntary weight loss with low muscle mass and health-related quality of life in a large representative sample of older adults. Methods: A nationwide cross-sectional study based on data from the Korea National Health and Nutritional Examination Survey, 2008 to 2011. Study participants included 2249 individuals aged >= 70 years. The participants reported an unintentional weight loss > 3 kg in the past year. Appendicular lean mass was measured using dual-energy X-ray absorptiometry and calculated with the appendicular lean mass index. Health-related quality of life was measured using the EuroQol-5 dimension (EQ-5D) instrument. Univariate and multivariate survey logistic regression models were used to calculate odds ratios (OR) with 95% confidence intervals (95% CI) for the lowest quintile of the EQ-5D index. Results: In total, 39.1% of participants were male and 60.9% were female. The weighted mean age was 75.6 years (95% CI; 75.3-75.9). Clinically significant weight loss is typically 5% of one's body weight; average, 2.8 kg (3.1 kg for men; 2.7 kg, women) for our participants. Compared with the normal reference group and after adjusting for potential confounders, the ORs for the lowest quintile of the EQ-5D indices were 1.39 (95% CI, 0.92-2.10), 2.56 (95% CI, 1.56-4.18), and 3.40 (95% CI, 2.05 to 5.63) for the low muscle mass, involuntary weight loss, involuntary weight loss with low muscle mass groups, respectively. Conclusion: Involuntary weight loss combined with low muscle mass was more closely associated with poor quality of life than involuntary weight loss alone in community-dwelling older adults.
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