Maltase Has Most Versatile alpha-Hydrolytic Activity Among the Mucosal alpha-Glucosidases of the Small Intestine
DC Field | Value | Language |
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dc.contributor.author | Lee, Byung-Hoo | - |
dc.contributor.author | Hamaker, Bruce R. | - |
dc.date.available | 2020-02-27T10:42:14Z | - |
dc.date.created | 2020-02-07 | - |
dc.date.issued | 2018-06 | - |
dc.identifier.issn | 0277-2116 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/3734 | - |
dc.description.abstract | Complete digestion of the glycemic carbohydrates to glucose takes place through the combined action of the 4 mucosal alpha-glucosidases (maltaseglucoamylase and sucrase-isomaltase) in the small intestine. Maltase digests alpha-1,2-and alpha-1,3-disaccharides better than the other alpha-glucosidases, and has, as well, the capability to effectively hydrolyze alpha-1,4 and alpha-1,6 linkages that form the major backbone of a starch molecule. This broad hydrolytic activity on alpha-linkages makes it an enzyme that has the most versatile alpha-hydrolytic activity among the 4 mucosal alpha-glucosidases. The slowly digestible properties of the unusual linkages from this research suggest the development of new glycemic oligosaccharides which will be hydrolyzed slowly, compared to alpha-1,4 linkages, for modulating the postprandial glycemic response. In addition, using mammalian mucosal alpha-glucosidases is a better fit to characterize carbohydrate digestion properties, compared to fungal amyloglucosidase which is currently applied in in vitro assays. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.relation.isPartOf | JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION | - |
dc.subject | GLUCOSE GENERATION | - |
dc.subject | SUCRASE-ISOMALTASE | - |
dc.subject | DISACCHARIDE INTOLERANCE | - |
dc.subject | GLUCOAMYLASE-MALTASE | - |
dc.subject | STARCH DIGESTION | - |
dc.subject | SPECIFICITY | - |
dc.subject | BIOSYNTHESIS | - |
dc.subject | INHIBITION | - |
dc.subject | SIZE | - |
dc.title | Maltase Has Most Versatile alpha-Hydrolytic Activity Among the Mucosal alpha-Glucosidases of the Small Intestine | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000441416200003 | - |
dc.identifier.doi | 10.1097/MPG.0000000000001954 | - |
dc.identifier.bibliographicCitation | JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, v.66, pp.S7 - S10 | - |
dc.identifier.scopusid | 2-s2.0-85064845986 | - |
dc.citation.endPage | S10 | - |
dc.citation.startPage | S7 | - |
dc.citation.title | JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION | - |
dc.citation.volume | 66 | - |
dc.contributor.affiliatedAuthor | Lee, Byung-Hoo | - |
dc.type.docType | Article; Proceedings Paper | - |
dc.subject.keywordAuthor | disaccharides | - |
dc.subject.keywordAuthor | glucose generation | - |
dc.subject.keywordAuthor | alpha-glucosidases | - |
dc.subject.keywordAuthor | alpha-linkages | - |
dc.subject.keywordAuthor | maltase | - |
dc.subject.keywordPlus | GLUCOSE GENERATION | - |
dc.subject.keywordPlus | SUCRASE-ISOMALTASE | - |
dc.subject.keywordPlus | DISACCHARIDE INTOLERANCE | - |
dc.subject.keywordPlus | GLUCOAMYLASE-MALTASE | - |
dc.subject.keywordPlus | STARCH DIGESTION | - |
dc.subject.keywordPlus | SPECIFICITY | - |
dc.subject.keywordPlus | BIOSYNTHESIS | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | SIZE | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalResearchArea | Pediatrics | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Pediatrics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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