Decursin and decursinol angelate improve wound healing by upregulating transcription of genes encoding extracellular matrix remodeling proteins, inflammatory cytokines, and growth factors in human keratinocytes
- Authors
- Han, Jisu; Jin, Wook; Ngoc Anh Ho; Hong, Jeongpyo; Kim, Yoon Ju; Shin, Yungyeong; Lee, Hanki; Suh, Joo-Won
- Issue Date
- 23-May-2018
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Citation
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.499, no.4, pp.979 - 984
- Journal Title
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Volume
- 499
- Number
- 4
- Start Page
- 979
- End Page
- 984
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/3761
- DOI
- 10.1016/j.bbrc.2018.04.031
- ISSN
- 0006-291X
- Abstract
- The coumarins decursin and decursinol angelate, which are found in Angelica gigas Nakai, have a variety of biological functions. Here, we show that treatment with these compounds improves wound healing by HaCaT human keratinocytes. Wound healing was increased by treatment with up to a threshold concentration of decursin, decursinol angelate, a mixture of both, and a nano-emulsion of these compounds, but inhibited by treatment with higher concentrations. lmmunoblotting and fluorescence imaging of cells expressing an epidermal growth factor receptor (EGFR) biosensor demonstrated that these compounds did not stimulate wound healing by inducing EGFR phosphorylation. Rather, transcriptional analysis revealed that decursin and decursinol angelate improved wound healing by upregulating the expression of genes encoding extracellular matrix remodeling proteins, inflammatory cytokines, and growth factors. (C) 2018 Elsevier Inc. All rights reserved.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 의과대학 > 의예과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/3761)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.