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A NEW PHENOLIC COMPOUND FROM SALIX GLANDULOSA

Authors
Kim, Chung SubSubedi, LalitaOh, JoonseokKim, Sun YeouChoi, Sang UnLee, Kang Ro
Issue Date
1-May-2018
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Keywords
Salix glandulosa; Phenolic Compound; ECD; Cytotoxicity; Anti-Inflammation
Citation
HETEROCYCLES, v.96, no.5, pp.935 - 946
Journal Title
HETEROCYCLES
Volume
96
Number
5
Start Page
935
End Page
946
URI
https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/3776
DOI
10.3987/COM-18-13892
ISSN
0385-5414
Abstract
A new phenolic compound, saliglandol (1), was isolated from Salix glandulosa along with 22 known ones. Their chemical structures were established through analyzing spectroscopic data. Comparison of calculated and experimental ECD spectra of 1 resulted in assignment of its absolute configuration. All isolated compounds (1-23) were evaluated for their cytotoxic activities against four human cancer cell lines (A549, SK-OV-3, SK-MEL-2, an BT549), anti-inflammatory effects measuring nitric oxide (NO) levels in lipopolysaccharide (LPS)-stimulated murine microglia BV2 cells, and potential neuroprotective effects through induction of nerve growth factor (NGF) in C6 glioma cells.
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