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A NEW PHENOLIC COMPOUND FROM SALIX GLANDULOSA
- Issue Date
- 1-May-2018
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Salix glandulosa; Phenolic Compound; ECD; Cytotoxicity; Anti-Inflammation
- Citation
- HETEROCYCLES, v.96, no.5, pp.935 - 946
- Journal Title
- HETEROCYCLES
- Volume
- 96
- Number
- 5
- Start Page
- 935
- End Page
- 946
- ISSN
- 0385-5414
- Abstract
- A new phenolic compound, saliglandol (1), was isolated from Salix glandulosa along with 22 known ones. Their chemical structures were established through analyzing spectroscopic data. Comparison of calculated and experimental ECD spectra of 1 resulted in assignment of its absolute configuration. All isolated compounds (1-23) were evaluated for their cytotoxic activities against four human cancer cell lines (A549, SK-OV-3, SK-MEL-2, an BT549), anti-inflammatory effects measuring nitric oxide (NO) levels in lipopolysaccharide (LPS)-stimulated murine microglia BV2 cells, and potential neuroprotective effects through induction of nerve growth factor (NGF) in C6 glioma cells.
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Related Researcher
- Kim, Sun Yeou
- Pharmacy (Dept.of Pharmacy)