Impact of Nodule Size on Malignancy Risk Differs according to the Ultrasonography Pattern of Thyroid Nodules
- Authors
- Hong, Min Ji; Na, Dong Gyu; Baek, Jung Hwan; Sung, Jin Yong; Kim, Ji-Hoon
- Issue Date
- May-2018
- Publisher
- KOREAN RADIOLOGICAL SOC
- Keywords
- Thyroid; Thyroid nodule; Thyroid malignancy; Ultrasonography; Tumor size; Nodule size; Risk of malignancy; Malignancy risk; Pattern analysis; Imaging analysis; Imaging pattern; Imaging feature
- Citation
- KOREAN JOURNAL OF RADIOLOGY, v.19, no.3, pp.534 - 541
- Journal Title
- KOREAN JOURNAL OF RADIOLOGY
- Volume
- 19
- Number
- 3
- Start Page
- 534
- End Page
- 541
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/3830
- DOI
- 10.3348/kjr.2018.19.3.534
- ISSN
- 1229-6929
- Abstract
- Objective: To test whether the impact of thyroid-nodule size on the malignancy risk differs according to the ultrasonography (US) patterns of nodules. Materials and Methods: This study is a post hoc analysis using data from the Thyroid Imaging Reporting and Data System (TIRADS) multicenter retrospective study which included 2000 consecutive thyroid nodules (>= 1 cm) with final diagnoses. A total of 2000 consecutive thyroid nodules from 1802 patients (1387 women and 613 men; mean age, 51.2 +/- 12.2 years) were enrolled in this study. The malignancy risk of the nodules was assessed according to the nodule size and US patterns (Korean-TIRADS). Results: Overall, the malignancy risk did not increase as nodules enlarged. In high-suspicion nodules, the malignancy rate had no association with nodule size (p = 0.467), whereas in intermediate-or low-suspicion nodules there was a trend toward an increasing malignancy risk as the nodule size increased (p = 0.004 and 0.002, respectively). The malignancy rate of large nodules (>= 3 cm) was higher than that of small nodules (< 3 cm) in intermediate-suspicion nodules (40.3% vs. 22.6%, respectively; p = 0.001) and low-suspicion nodules (11.3% vs. 7.0%, respectively; p = 0.035). There was a trend toward a decreasing risk and proportion of papillary carcinoma and an increasing risk and proportion of follicular carcinoma or other malignant tumors as nodule size increased (p < 0.001, respectively). Conclusion: The impact of nodule size on the malignancy risk differed according to the US pattern. A large nodule size (>= 3 cm) showed a higher malignancy risk than smaller nodules in intermediate-and low-suspicion nodules.
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