Protective effect of bovine milk against HCl and ethanol- induced gastric ulcer in mice
- Authors
- Yoo, Jeong-Hyun; Lee, Jeong-Sang; Lee, You-Suk; Ku, SaeKwang; Lee, Hae-Jeung
- Issue Date
- May-2018
- Publisher
- ELSEVIER SCIENCE INC
- Keywords
- bovine milk; gastric ulcer; gastroprotective effect; antioxidant enzyme activity; anti-inflammatory effect
- Citation
- JOURNAL OF DAIRY SCIENCE, v.101, no.5, pp.3758 - 3770
- Journal Title
- JOURNAL OF DAIRY SCIENCE
- Volume
- 101
- Number
- 5
- Start Page
- 3758
- End Page
- 3770
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/3832
- DOI
- 10.3168/jds.2017-13872
- ISSN
- 0022-0302
- Abstract
- The purpose of this study was to investigate the gastroprotective effects of bovine milk on an acidified ethanol (HCl-ethanol) mixture that induced gastric ulcers in a mouse model. Mice received different doses of commercial fresh bovine milk (5, 10, and 20 mL/kg of body weight) by oral gavage once a day for 14 d. One hour after the last oral administration of bovine milk, the HCl-ethanol mixture was orally intubated to provoke severe gastric damage. Our results showed that pretreatment with bovine milk significantly suppressed the formation of gastric mucosa lesions. Pretreatment lowered gastric myeloperoxidase and increased gastric mucus contents and antioxidant enzymes catalase and superoxide dismutase. Administration of bovine milk increased nitrate/nitrite levels and decreased the malondialdehyde levels and the expression of proinflammatory genes, including transcription factor nuclear factor-kappa B, cyclooxygenase-2, and inducible nitric oxide synthase in the stomach of mice. These results suggest that bovine milk can prevent the development of gastric ulcer caused by acid and alcohol in mice.
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Collections - 바이오나노대학 > 식품영양학과 > 1. Journal Articles
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