Beneficial Effects of Bioactive Compounds in Mulberry Fruits against Cisplatin-Induced Nephrotoxicity
DC Field | Value | Language |
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dc.contributor.author | Lee, Dahae | - |
dc.contributor.author | Yu, Jae Sik | - |
dc.contributor.author | Lee, Seoung Rak | - |
dc.contributor.author | Hwang, Gwi Seo | - |
dc.contributor.author | Kang, Ki Sung | - |
dc.contributor.author | Park, Jae Gyu | - |
dc.contributor.author | Kim, Hyun Young | - |
dc.contributor.author | Kim, Ki Hyun | - |
dc.contributor.author | Yamabe, Noriko | - |
dc.date.available | 2020-02-27T11:41:19Z | - |
dc.date.created | 2020-02-07 | - |
dc.date.issued | 2018-04 | - |
dc.identifier.issn | 1422-0067 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/3917 | - |
dc.description.abstract | Mulberry, the fruit of white mulberry tree (Morus alba L., Moraceae), is commonly used in traditional Chinese medicines as a sedative, tonic, laxative, and emetic. In our continuing research of the bioactive metabolites from mulberry, chemical analysis of the fruits led to the isolation of five compounds, 1-5. The compounds were identified as butyl pyroglutamate (1), quercetin 3-O-beta-D-glucoside (2), kaempferol 3-O-beta-D-rutinoside (3), rutin (4), and 2-phenylethyl D-rutinoside (5) by spectroscopic data analysis, comparing their nuclear magnetic resonance (NMR) data with those in published literature, and liquid chromatography-mass spectrometry analysis. The isolated compounds 1-5 were evaluated for their effects on anticancer drug-induced side effects by cell-based assays. Compound 1 exerted the highest protective effect against cisplatin-induced kidney cell damage. This effect was found to be mediated through the attenuation of phosphorylation of c-Jun N-terminal kinase, extracellular signal-regulated kinase, p38, mitogen-activated protein kinase, and caspase-3 in cisplatin-induced kidney cell damage. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.subject | CERVICAL-CANCER | - |
dc.subject | KIDNEY-CELLS | - |
dc.subject | INDUCED CYTOTOXICITY | - |
dc.subject | INDUCED APOPTOSIS | - |
dc.subject | L. | - |
dc.subject | EXTRACTS | - |
dc.subject | TOXICITY | - |
dc.subject | ANALOGS | - |
dc.subject | GROWTH | - |
dc.subject | INJURY | - |
dc.title | Beneficial Effects of Bioactive Compounds in Mulberry Fruits against Cisplatin-Induced Nephrotoxicity | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000434978700196 | - |
dc.identifier.doi | 10.3390/ijms19041117 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.19, no.4 | - |
dc.identifier.scopusid | 2-s2.0-85045223343 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.volume | 19 | - |
dc.citation.number | 4 | - |
dc.contributor.affiliatedAuthor | Hwang, Gwi Seo | - |
dc.contributor.affiliatedAuthor | Kang, Ki Sung | - |
dc.contributor.affiliatedAuthor | Yamabe, Noriko | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | mulberry | - |
dc.subject.keywordAuthor | Morus alba | - |
dc.subject.keywordAuthor | cisplatin | - |
dc.subject.keywordAuthor | nephrotoxicity | - |
dc.subject.keywordAuthor | mitogen-activated protein kinases | - |
dc.subject.keywordAuthor | caspase-3 | - |
dc.subject.keywordPlus | CERVICAL-CANCER | - |
dc.subject.keywordPlus | KIDNEY-CELLS | - |
dc.subject.keywordPlus | INDUCED CYTOTOXICITY | - |
dc.subject.keywordPlus | INDUCED APOPTOSIS | - |
dc.subject.keywordPlus | L. | - |
dc.subject.keywordPlus | EXTRACTS | - |
dc.subject.keywordPlus | TOXICITY | - |
dc.subject.keywordPlus | ANALOGS | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | INJURY | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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