Beneficial Effects of Bioactive Compounds in Mulberry Fruits against Cisplatin-Induced Nephrotoxicity
- Authors
- Lee, Dahae; Yu, Jae Sik; Lee, Seoung Rak; Hwang, Gwi Seo; Kang, Ki Sung; Park, Jae Gyu; Kim, Hyun Young; Kim, Ki Hyun; Yamabe, Noriko
- Issue Date
- Apr-2018
- Publisher
- MDPI
- Keywords
- mulberry; Morus alba; cisplatin; nephrotoxicity; mitogen-activated protein kinases; caspase-3
- Citation
- INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.19, no.4
- Journal Title
- INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Volume
- 19
- Number
- 4
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/3917
- DOI
- 10.3390/ijms19041117
- ISSN
- 1422-0067
- Abstract
- Mulberry, the fruit of white mulberry tree (Morus alba L., Moraceae), is commonly used in traditional Chinese medicines as a sedative, tonic, laxative, and emetic. In our continuing research of the bioactive metabolites from mulberry, chemical analysis of the fruits led to the isolation of five compounds, 1-5. The compounds were identified as butyl pyroglutamate (1), quercetin 3-O-beta-D-glucoside (2), kaempferol 3-O-beta-D-rutinoside (3), rutin (4), and 2-phenylethyl D-rutinoside (5) by spectroscopic data analysis, comparing their nuclear magnetic resonance (NMR) data with those in published literature, and liquid chromatography-mass spectrometry analysis. The isolated compounds 1-5 were evaluated for their effects on anticancer drug-induced side effects by cell-based assays. Compound 1 exerted the highest protective effect against cisplatin-induced kidney cell damage. This effect was found to be mediated through the attenuation of phosphorylation of c-Jun N-terminal kinase, extracellular signal-regulated kinase, p38, mitogen-activated protein kinase, and caspase-3 in cisplatin-induced kidney cell damage.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 한의과대학 > 한의예과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/3917)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.