Development of solidified self-microemulsifying drug delivery systems containing L-tetrahydropalmatine: Design of experiment approach and bioavailability comparison
DC Field | Value | Language |
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dc.contributor.author | Nguyen-Thach Tung | - |
dc.contributor.author | Cao-Son Tran | - |
dc.contributor.author | Thi-Minh-Hue Pham | - |
dc.contributor.author | Hoang-Anh Nguyen | - |
dc.contributor.author | Tran-Linh Nguyen | - |
dc.contributor.author | Chi, Sang-Cheol | - |
dc.contributor.author | Dinh-Duc Nguyen | - |
dc.contributor.author | Thi-Bich-Huong Bui | - |
dc.date.available | 2020-02-27T11:42:18Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2018-02-15 | - |
dc.identifier.issn | 0378-5173 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/4054 | - |
dc.description.abstract | The study first aimed to apply a design of experiment (DoE) approach to investigate the influences of excipients on the properties of liquid self-microemulsifying drug delivery system (SMEDDS) and SMEDDS loaded in the pellet (pellet-SMEDDS) containing L-tetrahydropalmatine (l-THP). Another aim of the study was to compare the bioavailability of l-THP suspension, liquid SMEDDS and pellet-SMEDDS in the rabbit model. By using Central Composite Face design (CCF), the optimum ratio of Capryol 90, and S-mix '(Cremophor RH 40: Transcutol HP) in the formulation of SMEDDS was determined. This optimum SMEDDS was absorbed on the solid carrier (Avicel or Aerosil) for the preparation of pellet-SMEDDS by extrusion and spheronization method. The ANOVA table indicated that Avicel was more effective than Aerosil, the traditional solid carrier, in both terms of preservation of dissolution rate of l-THP from the original SMEDDS and pelletization yield. Results obtained from scanning electron microscopy (SEM) indicated that the existence of liquid SMEDDS droplets on the surface of pellet-SMEDDS was due to the absorption on Avicel. The powder X-ray diffractometry proved the amorphous state of l-THP in pellet-SMEDDS. Pharmacokinetic study in the rabbit model using liquid chromatography tandem mass spectrometry showed that the SMEDDS improved the oral bioavailability of l-THP by 198.63% compared to l-THP suspension. Besides, pharmacokinetics study also proved that the mean relative bioavailability (AUC) and mean maximum concentration (C-max) of pellet-SMEDDS were not significantly different from the original liquid SMEDDS (p > 0.05). | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF PHARMACEUTICS | - |
dc.subject | TANDEM MASS-SPECTROMETRY | - |
dc.subject | LIPID-BASED FORMULATIONS | - |
dc.subject | ORAL BIOAVAILABILITY | - |
dc.subject | LEVO-TETRAHYDROPALMATINE | - |
dc.subject | TISSUE DISTRIBUTION | - |
dc.subject | SMEDDS | - |
dc.subject | ENHANCEMENT | - |
dc.subject | LIQUID | - |
dc.subject | PHARMACOKINETICS | - |
dc.subject | PERFORMANCE | - |
dc.title | Development of solidified self-microemulsifying drug delivery systems containing L-tetrahydropalmatine: Design of experiment approach and bioavailability comparison | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000424263700002 | - |
dc.identifier.doi | 10.1016/j.ijpharm.2017.12.027 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF PHARMACEUTICS, v.537, no.1-2, pp.9 - 21 | - |
dc.identifier.scopusid | 2-s2.0-85037971920 | - |
dc.citation.endPage | 21 | - |
dc.citation.startPage | 9 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF PHARMACEUTICS | - |
dc.citation.volume | 537 | - |
dc.citation.number | 1-2 | - |
dc.contributor.affiliatedAuthor | Chi, Sang-Cheol | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | L-Tetrahydropalmatine | - |
dc.subject.keywordAuthor | Self-microemulsifying drug delivery system | - |
dc.subject.keywordAuthor | Pellet | - |
dc.subject.keywordAuthor | Solubility | - |
dc.subject.keywordAuthor | Bioavailability | - |
dc.subject.keywordPlus | TANDEM MASS-SPECTROMETRY | - |
dc.subject.keywordPlus | LIPID-BASED FORMULATIONS | - |
dc.subject.keywordPlus | ORAL BIOAVAILABILITY | - |
dc.subject.keywordPlus | LEVO-TETRAHYDROPALMATINE | - |
dc.subject.keywordPlus | TISSUE DISTRIBUTION | - |
dc.subject.keywordPlus | SMEDDS | - |
dc.subject.keywordPlus | ENHANCEMENT | - |
dc.subject.keywordPlus | LIQUID | - |
dc.subject.keywordPlus | PHARMACOKINETICS | - |
dc.subject.keywordPlus | PERFORMANCE | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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