Tumor Boost Using External Beam Radiation in Cervical Cancer Patients Unable to Receive Intracavitary Brachytherapy Outcome From a Multicenter Retrospective Study (Korean Radiation Oncology Group 1419)
- Authors
- Kim, Haeyoung; Kim, Young Seok; Joo, Ji Hyeon; Eom, Keun-Yong; Park, Won; Kim, Jin Hee; Lee, Jong Hoon; Kim, Yeon Sil; Lee, Seok Ho; Ahn, Kijung; Kim, Yong Bae; Lee, Me-Yeon; Chang, Sei Kyung
- Issue Date
- Feb-2018
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS
- Keywords
- Brachytherapy; Radiotherapy; Uterine cervical neoplasm
- Citation
- INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, v.28, no.2, pp.371 - 378
- Journal Title
- INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
- Volume
- 28
- Number
- 2
- Start Page
- 371
- End Page
- 378
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/4129
- DOI
- 10.1097/IGC.0000000000001155
- ISSN
- 1048-891X
- Abstract
- Purpose: We conducted this study to evaluate the outcomes of external-beam radiotherapy tumor boost (EBRT-B) in cervical cancer patients who could not receive intracavitary brachytherapy. Methods: A total of 11 hospitals provided the data of patients who received EBRT-B during the period from January 2005 through October 2012. Results: A total of 75 patients were included. The median radiotherapy dose was 46 Gy (range, 40-54 Gy) for whole pelvis and 24 Gy (range, 9-35 Gy) for EBRT-B. Initial tumor responses assessed at 2 to 6 months after radiotherapy were as follows: 46 with complete response, 22with partial response, 2with stable disease, and 3with progressive disease. After a median follow-up time of 33 months, 30 patients (40.0%) showed disease progression including 21 (28.0%) with local progression. The 5-year local failure-free survival rate was 70.0%. Achieving complete response at the first follow-up visit and an overall treatment timeof 53 days or less were significantly related to favorable local failure-free survival. The rate of grade 3 or higher toxicity was 2.6%. Conclusions: Approximately 70% of patients had local tumor control after curative radiotherapy using EBRT-B. Early tumor response and overall treatment time of 53 days or lesswere closely associated with favorable local control.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 의과대학 > 의학과 > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.