Mesenchymal Stromal Cells Inhibit Inflammatory Lymphangiogenesis in the Cornea by Suppressing Macrophage in a TSG-6-Dependent Manner
- Authors
- Song, Hyun Beom; Park, Se Yeon; Ko, Jung Hwa; Park, Jong Woo; Yoon, Chang Ho; Kim, Dong Hyun; Kim, Jeong Hun; Kim, Mee Kum; Lee, Ryang Hwa; Prockop, Darwin J.; Oh, Joo Youn
- Issue Date
- 3-Jan-2018
- Publisher
- CELL PRESS
- Citation
- MOLECULAR THERAPY, v.26, no.1, pp.162 - 172
- Journal Title
- MOLECULAR THERAPY
- Volume
- 26
- Number
- 1
- Start Page
- 162
- End Page
- 172
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/4153
- DOI
- 10.1016/j.ymthe.2017.09.026
- ISSN
- 1525-0016
- Abstract
- The cornea is a transparent tissue devoid of blood and lymphatic vessels. However, various inflammatory conditions can cause hemangiogenesis and lymphangiogenesis in the cornea, compromising transparency and visual acuity. Mesenchymal stem/stromal cells (MSCs) have therapeutic potentials in a variety of diseases because of anti-inflammatory proper- ties. Herein, we investigated the effects of MSCs on corneal angiogenesis using a model of suture-induced inflammatory corneal neovascularization. Data demonstrated that an intravenous administration of MSCs suppressed corneal inflammation and neovascularization, inhibiting both hemangiogenesis and lymphangiogenesis. MSCs reduced the levels of vascular endothelial growth factor (VEGF)-C, VEGF-D, Tek, MRC1, and MRC2 in the cornea, which are expressed by pro-angiogenic macrophages. Moreover, the number of CD11b(+) monocytes/macrophages in the cornea, spleen, peripheral blood, and draining lymph nodes was decreased by MSCs. Depletion of circulating CD11b(+) monocytes by blocking antibodies replicated the effects of MSCs. Importantly, knockdown of tumor necrosis factor alpha (TNF-alpha)-stimulated gene/protein 6 (TSG-6) in MSCs abrogated the effects of MSCs in inhibiting corneal hemangiogenesis and lymphangiogenesis and monocyte/macrophage infiltration. Together, the results suggest that MSCs inhibit inflammatory neovascularization in the cornea by suppressing pro-angiogenic monocyte/macrophage recruitment in a TSG-6-dependent manner.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 의과대학 > 의학과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/4153)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.