Bee venom phospholipase A2 induces regulatory T cell populations by suppressing apoptotic signaling pathway
DC Field | Value | Language |
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dc.contributor.author | Baek H. | - |
dc.contributor.author | Park S.-Y. | - |
dc.contributor.author | Ku S.J. | - |
dc.contributor.author | Ryu K. | - |
dc.contributor.author | Kim Y. | - |
dc.contributor.author | Bae H. | - |
dc.contributor.author | Lee Y.-S. | - |
dc.date.available | 2020-04-28T04:35:17Z | - |
dc.date.created | 2020-04-16 | - |
dc.date.issued | 2020-03 | - |
dc.identifier.issn | 2072-6651 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/41605 | - |
dc.description.abstract | Bee venom phospholipase A2 is a lipolytic enzyme in bee venom that catalyzes hydrolysis of the sn-2 ester bond of membrane phospholipids to produce free fatty acid and lysophospholipids. Current evidence suggests that bee venom phospholipase A2 (bvPLA2) induces regulatory T cell expansion and attenuates several immune system-related diseases, including Alzheimer’s disease. The induction of Treg cells is directly mediated by binding to mannose receptors on dendritic cells. This interaction induces the PGE2-EP2 signaling pathway, which promotes Treg induction in CD4+ T cells. In this study, we investigated the effects of bvPLA2 treatment on the apoptotic signaling pathway in Treg populations. Flow cytometry was performed to identify early apoptotic cells. As a result, early apoptotic cells were dramatically decreased in bvPLA2-treated splenocytes, whereas rapamycin-treated cells showed levels of apoptotic cells similar to those of PBS-treated cells. Furthermore, bvPLA2 treatment increased expression of anti-apoptotic molecules including CTLA-4 and PD-1. The survival rate increased in bvPLA2-treated Tregs. Our findings indicate that bvPLA2-mediated modulation of apoptotic signaling is strongly associated with the Treg induction, which exhibits protective effects against various immune-related diseases. To our knowledge, this study is the first to demonstrate that bvPLA2 is the major bee venom (BV) compound capable of inducing Treg expansion through altering apoptotic signal. © 2020 by the authors. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI AG | - |
dc.relation.isPartOf | Toxins | - |
dc.title | Bee venom phospholipase A2 induces regulatory T cell populations by suppressing apoptotic signaling pathway | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000525009500033 | - |
dc.identifier.doi | 10.3390/toxins12030198 | - |
dc.identifier.bibliographicCitation | Toxins, v.12, no.3 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85082536485 | - |
dc.citation.title | Toxins | - |
dc.citation.volume | 12 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | Ku S.J. | - |
dc.contributor.affiliatedAuthor | Kim Y. | - |
dc.contributor.affiliatedAuthor | Lee Y.-S. | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Apoptosis | - |
dc.subject.keywordAuthor | Bee venom phospholipase A2 | - |
dc.subject.keywordAuthor | BvPLA2 | - |
dc.subject.keywordAuthor | Regulatory T cells | - |
dc.subject.keywordAuthor | Tregs | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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