Impact of Significant Mitral Regurgitation on Assessing the Severity of Aortic Stenosis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Pil Hyung | - |
dc.contributor.author | Hong, Jung Ae | - |
dc.contributor.author | Sun, Byung Joo | - |
dc.contributor.author | Han, Seungbong | - |
dc.contributor.author | Park, Sangwoo | - |
dc.contributor.author | Jang, Jeong Yoon | - |
dc.contributor.author | Kim, Dae-Hee | - |
dc.contributor.author | Kang, Duk-Hyun | - |
dc.contributor.author | Song, Jae-Kwan | - |
dc.contributor.author | Song, Jong-Min | - |
dc.date.available | 2020-02-27T12:42:12Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2018-01 | - |
dc.identifier.issn | 0894-7317 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/4235 | - |
dc.description.abstract | Background: Significant mitral regurgitation (MR) may reduce a pressure gradient of aortic stenosis (AS) by decreasing forward stroke volume. The study objective was to evaluate whether significant MR can cause inconsistency when assessing the severity of AS. Methods: Among 5,355 patients diagnosed with AS from 2000 to 2015, 68 were retrospectively found to have concomitant significant (moderate or greater) MR and normal left ventricular ejection fractions in normal sinus rhythm (AS with MR). As a control group, 136 patients with trivial or no MR were selected who were matched by age, gender, and left ventricular end-systolic volume (AS without MR). Nonlinear regression was performed for data pairs (aortic valve area [AVA] vs mean pressure gradient [MPG]) using the formula AVA = a + b root OMPG. Composite clinical events were defined as aortic valve surgery warranted by the development of symptoms or left ventricular dysfunction, admission because of heart failure, and death. Results: The forward stroke volume index was significantly lower in the AS with MR group than in the AS without MR group (43.86 +/- 8.3 vs 49.26 +/- 10.2 mL/m(2), P <.004). A significant group difference was found with respect to the relationship between (indexed) AVA and MPG (AVA, 0.02 + 4.43/root MPG vs -0.06 + 5.60/OMPG [P for interaction =.04]; indexed AVA, 0.03 + 2.66/root MPG vs -0.03 + 3.47/OMPG [P for interaction =.01]). An AVA of 1.0 cm(2) corresponded to MPGs of 20.3 and 28.2mmHg for the groups with and without MR, respectively. Conversely, an MPG of 40mm Hg corresponded to AVAs of 0.72 and 0.83 cm(2) for the groups with and without MR, respectively. Among patients with MPGs < 40mm Hg, clinical event rates were significantly higher in those with MR compared with those without MR (P =.009). Conclusions: This quantitative analysis demonstrated that AS severity assessed by MPG measurement may be underestimated, and thus AVA measurement is essential in patients with combined significant MR. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MOSBY-ELSEVIER | - |
dc.relation.isPartOf | JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY | - |
dc.subject | VALVULAR HEART-DISEASE | - |
dc.subject | PRESERVED EJECTION FRACTION | - |
dc.subject | VALVE STENOSIS | - |
dc.subject | ECHOCARDIOGRAPHIC-ASSESSMENT | - |
dc.subject | TASK-FORCE | - |
dc.subject | GUIDELINES | - |
dc.subject | MANAGEMENT | - |
dc.subject | CATHETERIZATION | - |
dc.subject | RECOMMENDATIONS | - |
dc.subject | PREDICTORS | - |
dc.title | Impact of Significant Mitral Regurgitation on Assessing the Severity of Aortic Stenosis | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000419223600003 | - |
dc.identifier.doi | 10.1016/j.echo.2017.09.012 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY, v.31, no.1, pp.26 - 33 | - |
dc.identifier.scopusid | 2-s2.0-85034102155 | - |
dc.citation.endPage | 33 | - |
dc.citation.startPage | 26 | - |
dc.citation.title | JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY | - |
dc.citation.volume | 31 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Han, Seungbong | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Aortic stenosis | - |
dc.subject.keywordAuthor | Mitral regurgitation | - |
dc.subject.keywordAuthor | Echocardiography | - |
dc.subject.keywordPlus | VALVULAR HEART-DISEASE | - |
dc.subject.keywordPlus | PRESERVED EJECTION FRACTION | - |
dc.subject.keywordPlus | VALVE STENOSIS | - |
dc.subject.keywordPlus | ECHOCARDIOGRAPHIC-ASSESSMENT | - |
dc.subject.keywordPlus | TASK-FORCE | - |
dc.subject.keywordPlus | GUIDELINES | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | CATHETERIZATION | - |
dc.subject.keywordPlus | RECOMMENDATIONS | - |
dc.subject.keywordPlus | PREDICTORS | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.