Phytochemical constituents of capsella bursa-pastoris and their anti-inflammatory activity
- Authors
- Cha, J.M.; Kim, D.H.; Lee, T.H.; Subed, L.; Kim, S.Y.; Lee, K.R.
- Issue Date
- Jun-2018
- Publisher
- Korean Society of Pharmacognosy
- Keywords
- Capsella bursa-pastoris; Cruciferae; Sulfur compound
- Citation
- Natural Product Sciences, v.24, no.2, pp.132 - 138
- Journal Title
- Natural Product Sciences
- Volume
- 24
- Number
- 2
- Start Page
- 132
- End Page
- 138
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/4292
- DOI
- 10.20307/nps.2018.24.2.132
- ISSN
- 1226-3907
- Abstract
- Phytochemical investigation of 80% MeOH extract of the aerial parts of Capsella bursa-pastoris yielded fourteen compounds (1 - 14). The structures of the compounds were elucidated by spectroscopic methods to be methyl-1-thio-β-D-glucopyranosyl disulfide (1), 10-methylsulphinyl-decanenitrile (2), 11-methyl-sulphinyl-undecanenitrile (3), 1-O-(lauroyl)glycerol (4), phytene-1, 2-diol (5), (3S,5R,6S,7E)-5,6-epoxy-3-hydroxy-7-megastigmen-9-one (6), loliolide (7), β-sitosterol (8), 3-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-1-propanone (9), 1-feruloyl-β-D-glucopyranoside (10), pinoresinol-4'-O-β-D-glucopyranoside (11), luteolin (12), quercetin-3-O-β-D-glucopyranoside (13), and luteolin 6-C-β-glucopyranoside (14). Although compound 1 was reported as synthetic compound, 1 was first isolated from natural source. NMR spectral data assignments of 1, 2 and 3 were reported for the first time, and compounds 1 - 14 were for the first time reported from this plant source. The anti-inflammatory effects of 1 - 14 were evaluated in lipopolysaccharide (LPS)-stimulated murine microglia BV-2 cells. Compounds 12 exhibited strong inhibitory effects on nitric oxide production in LPS-activated BV-2 cells with IC 50 values of 9.70 µM. © 2018, Korean Society of Pharmacognosy. All rights reserved.
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