The effect of Glucopyranosyldiacylglycerol from Padina arborescens on the prevention of hair-loss부챗말 Glucopyranosyldiacylglycerol의 탈모방지 효능
- Other Titles
- 부챗말 Glucopyranosyldiacylglycerol의 탈모방지 효능
- Authors
- Kang J.-I.; Kim J.; Kim S.-C.; Han S.-C.; Lee J.-H.; Lee J.; Noh E.; Jeon Y.-J.; Yoo E.-S.; Kang H.-K.
- Issue Date
- Mar-2020
- Publisher
- Korean Society of Pharmacognosy
- Keywords
- 5α-Reductase; Dermal papilla cell; Glucopyranosyldiacylglycerol; Hair-loss; KATP channel; Padina arborescens
- Citation
- Korean Journal of Pharmacognosy, v.51, no.1, pp.41 - 48
- Journal Title
- Korean Journal of Pharmacognosy
- Volume
- 51
- Number
- 1
- Start Page
- 41
- End Page
- 48
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/44005
- ISSN
- 0253-3073
- Abstract
- This study was conducted to evaluate the effects of Padina arborescens and 1-O-myristoyl-2-O-oleoyl-3-O-(α-D-glucopyranosyl)-glycerol(MOGG), its active component, on the prevention of hair loss. The P. arborescens extract and MOGG inhibited the activity of 5 α-reductase, which converts testosterone to dihydrotestosterone(DHT), a main cause of androgenetic alopecia. When immortalized rat vibrissa dermal papilla cells were treated with MOGG, the proliferation of dermal papilla cells significantly increased. In addition, we found that the P arborescens extract and MOGG could open the KATP channel, which may contribute to increase hair growth. Furthermore, MOGG promoted PGE2 production in HaCaT cells. The results suggest that MOGG from the P arborescens extract has the potential to treat alopecia via 5α-reductase inhibition, the proliferation of dermal papilla, the opening of the KATP channel and/or increase of PGE2 production. © 2020, Korean Society of Pharmacognosy. All rights reserved.
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