난소절제 동물모델을 이용한 폐경 후의 비만에 대한 건강 추출물의 효능에 대한 실험적 고찰The Experimental Study of the Beneficial Effect of Zingiberis Rhizoma on Post-menopausal Obesity Using Ovariectomized Rats
- Other Titles
- The Experimental Study of the Beneficial Effect of Zingiberis Rhizoma on Post-menopausal Obesity Using Ovariectomized Rats
- Authors
- 박창현; 임형호
- Issue Date
- 2018
- Publisher
- 대한한의학회
- Keywords
- Zingiberis rhizoma; Menopause; Obesity; Rat
- Citation
- 대한한의학회지, v.39, no.2, pp.106 - 118
- Journal Title
- 대한한의학회지
- Volume
- 39
- Number
- 2
- Start Page
- 106
- End Page
- 118
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/4956
- DOI
- 10.13048/jkm.18019
- ISSN
- 1010-0695
- Abstract
- Objectives: This study was performed to investigate anti-obesity effects of Zingiberis Rhizoma on ovariectomized rats in order to determine the possibility of the clinical use in preventing and treating post-menopausal obesity.
Methods: To investigate how menopause affects obesity in woman, rats were treated with Zingiberis Rhizoma extracts.
We measured various biomarkers including GOT,GPT, leptin, ghrelin, adiponectin, PPAR-γ mRNA, total cholesterol, triglyceride, HDL-cholesterol, liver weight, estradiol, uterine weight, and calcitonin, which are linked with obesity and menopause.
Results: There was a significant decrease in group which was given Zingiberis Rhizoma extracts 100 mg/kg and lipid level found in blood(total cholesterol, triglyceride). Fat accumulation of liver cells was repressed, liver function was improved and leptin and adipomectin levels were significantly normalized. In addition, expression of PPAR-γ was significantly increased.
Conclusions: The results indicated that Zingiberis Rhizoma extracts have anti-obesity effects on ovariectomized rats through improving liver function and lipid metabolic function.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 한의과대학 > 한의예과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/4956)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.