The rs6265 Polymorphism of the BDNF Gene Is Related to Higher-Lethality Suicide Attempts in the Korean PopulationThe rs6265 Polymorphism of the BDNF Gene Is Related to Higher-Lethality Suicide Attempts in the Korean Population
- Other Titles
- The rs6265 Polymorphism of the BDNF Gene Is Related to Higher-Lethality Suicide Attempts in the Korean Population
- Authors
- Kang Seung-Gul; Lee Jong Hun; Lee Kwanghun; Kim Hee-Cheol; Seo Wan Seok; Won Seunghee
- Issue Date
- May-2020
- Publisher
- 대한신경정신의학회
- Keywords
- Suicide attempt; Lethality; Brain derived neurotrophic factor; Gene; rs6265.
- Citation
- PSYCHIATRY INVESTIGATION, v.17, no.5, pp.417 - 423
- Journal Title
- PSYCHIATRY INVESTIGATION
- Volume
- 17
- Number
- 5
- Start Page
- 417
- End Page
- 423
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/51597
- DOI
- 10.30773/pi.2020.0012
- ISSN
- 1738-3684
- Abstract
- Objective Since the risk of suicide cannot be predicted by clinical symptoms alone, and suicide is known to have a genetic component, the discovery of genetic markers that can predict the lethality of suicide attempts is a clinically important topic. There have been many studies aiming to determine whether the rs6265 polymorphism of the BDNF gene is associated with suicidality; however, the results have been mixed, and there have been few studies investigating the relationship between this polymorphism and suicide attempt lethality.
Methods We assessed suicide lethality in 258 individuals who had attempted suicide using the relative risk ratio (RRR) scale and by genotyping the rs6265 polymorphism of the BDNF gene.
Results The RRR score for suicide attempts was higher in subjects with Met/Val and Val/Val genotypes than in that with a Met/Met genotype (p=0.015). The RRR score for suicide attempts was also higher in Val allele carriers (Met/Val+Val/Val) than in Met/Met homozygotes (p=0.006).
Conclusion This study demonstrates the possibility that the rs6265 polymorphism of the BDNF gene could be used as a genetic marker to predict the lethality of suicide attempts, but more replication studies are needed for the application of this result in clinical practice.
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