Development of arginine-glycine-aspartate-immobilized 3D printed poly(propylene fumarate) scaffolds for cartilage tissue engineering
- Authors
- Ahn, Chi Bum; Kim, Youngjo; Park, Sung Jean; Hwang, Yongsung; Lee, Jin Woo
- Issue Date
- Jun-2018
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- Micro-stereolithography (MSTL); poly(propylene fumarate) (PPF); macroporous scaffold; RGD peptide; chondrocytes; proliferation; cartilage tissue engineering
- Citation
- JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, v.29, no.7-9, pp.917 - 931
- Journal Title
- JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
- Volume
- 29
- Number
- 7-9
- Start Page
- 917
- End Page
- 931
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/5223
- DOI
- 10.1080/09205063.2017.1383020
- ISSN
- 0920-5063
- Abstract
- Poly(propylene fumarate) (PPF) has known to be a good candidate material for cartilage tissue regeneration because of its excellent mechanical properties during its degradation processes. Here, we describe the potential application of PPF-based materials as 3D printing bioinks to create macroporous cell scaffolds using micro-stereolithography. To improve cell-matrix interaction of seeded human chondrocytes within the PPF-based 3D scaffolds, we immobilized arginine-glycine-aspartate (RGD) peptide onto the PPF scaffolds. We also evaluated various cellular behaviors of the seeded chondrocytes using MTS assay, microscopic and histological analyses. The results indicated that PPF-based biocompatible scaffolds with immobilized RGD peptide could effectively support initial adhesion and proliferation of human chondrocytes. Such a 3D bio-printable scaffold can offer an opportunity to promote cartilage tissue regeneration.
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Collections - 의과대학 > 의예과 > 1. Journal Articles
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