Impedance Characterization of Chitosan Cytotoxicity to MCF-7 Breast Cancer Cells Using a Multidisc Indium Tin Oxide Microelectrode Array
DC Field | Value | Language |
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dc.contributor.author | Park, Ilhwan | - |
dc.contributor.author | Nguyen, Tra | - |
dc.contributor.author | Park, Jinsoo | - |
dc.contributor.author | Yoo, Ah Young | - |
dc.contributor.author | Park, Jae Kweon | - |
dc.contributor.author | Cho, Sungbo | - |
dc.date.available | 2020-02-27T15:43:11Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0013-4651 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/5238 | - |
dc.description.abstract | Chitosan is an amino polysaccharide with possible biomedical applications, for example, in bandage materials or as an antibacterial agent or a cytotoxic agent for tumor and cancer cells. In this study, the cytotoxic effect of chitosan (CTSN-P) on MCF-7 breast cancer cells was monitored in a nondestructive and real-time manner by electrical cell-substrate impedance sensing with a fabricated multidisc indium tin oxide electrode array. The electrical impedance characteristics of cell growth on the multidisc electrode were analyzed by equivalent electric circuit modeling. Application of CTSN-P caused deterioration of viability of cells on the electrode substrate and yielded a CTSN-P concentration-dependent decrease in impedance. The 50% cytotoxicity concentrations in a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and impedimetric assay were 1266.60 and 543.17 mu g/mL, respectively. Thus, impedance measurement is suitable for detecting low-dose effects of CTSN-P on the behavior or morphology of live cells. (C) 2018 The Electrochemical Society. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELECTROCHEMICAL SOC INC | - |
dc.relation.isPartOf | JOURNAL OF THE ELECTROCHEMICAL SOCIETY | - |
dc.subject | ANTIMICROBIAL ACTIVITY | - |
dc.subject | MONITOR CHANGES | - |
dc.subject | ASSAY | - |
dc.subject | NANOPARTICLES | - |
dc.subject | SCAFFOLDS | - |
dc.subject | SHAPE | - |
dc.title | Impedance Characterization of Chitosan Cytotoxicity to MCF-7 Breast Cancer Cells Using a Multidisc Indium Tin Oxide Microelectrode Array | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000431786800063 | - |
dc.identifier.doi | 10.1149/2.1201802jes | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE ELECTROCHEMICAL SOCIETY, v.165, no.2, pp.B55 - B59 | - |
dc.identifier.scopusid | 2-s2.0-85048439086 | - |
dc.citation.endPage | B59 | - |
dc.citation.startPage | B55 | - |
dc.citation.title | JOURNAL OF THE ELECTROCHEMICAL SOCIETY | - |
dc.citation.volume | 165 | - |
dc.citation.number | 2 | - |
dc.contributor.affiliatedAuthor | Park, Ilhwan | - |
dc.contributor.affiliatedAuthor | Nguyen, Tra | - |
dc.contributor.affiliatedAuthor | Park, Jinsoo | - |
dc.contributor.affiliatedAuthor | Yoo, Ah Young | - |
dc.contributor.affiliatedAuthor | Park, Jae Kweon | - |
dc.contributor.affiliatedAuthor | Cho, Sungbo | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | ANTIMICROBIAL ACTIVITY | - |
dc.subject.keywordPlus | MONITOR CHANGES | - |
dc.subject.keywordPlus | ASSAY | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | SCAFFOLDS | - |
dc.subject.keywordPlus | SHAPE | - |
dc.relation.journalResearchArea | Electrochemistry | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Electrochemistry | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Coatings & Films | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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