Microneedles containing cross-linked hyaluronic acid particulates for control of degradation and swelling behaviour after administration into skin
DC Field | Value | Language |
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dc.contributor.author | Choi, Jun-Tae | - |
dc.contributor.author | Park, Sang-Jin | - |
dc.contributor.author | Park, Jung-Hwan | - |
dc.date.available | 2020-02-27T15:43:34Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2018-11 | - |
dc.identifier.issn | 1061-186X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/5267 | - |
dc.description.abstract | Microneedles (MN) containing cross-linked hyaluronic acid (X-linked HA) particulates were prepared to control the degradation and swelling behaviour after transdermal drug delivery. The X-linked HA particulates were prepared by cross-linking HA chains and then passing the particulates through a sieve. Then, microneedles were prepared by micromolding method. The rheological properties of X-linked HA were studied. The penetration success rate, mechanical failure and dissolution rate of microneedles containing only hyaluronic acid (HA MN) and microneedles containing X-linked HA were compared. The delivery of fluorescein into the skin with X-linked HA MN was also observed using a confocal microscope. The size of the pulverised particulates in water ranged between 29 and 82 mu m in diameter. The HA MN and X-linked HA MN were 270 mu m in length. X-linked HA MN with fluorescein was inserted to a depth of 90% of the microneedle length successfully. There was no decrease in the penetration success rate for MN with up to 20% content of X-linked HA particulates. X-linked HA MN with up to 20% of particulate content did not change the dissolution time. Delay in degradation of HA, sustained drug release, and swelling behaviour of the skin layer can be obtained by X-linked HA MN. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.relation.isPartOf | JOURNAL OF DRUG TARGETING | - |
dc.title | Microneedles containing cross-linked hyaluronic acid particulates for control of degradation and swelling behaviour after administration into skin | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000446112000003 | - |
dc.identifier.doi | 10.1080/1061186X.2018.1435664 | - |
dc.identifier.bibliographicCitation | JOURNAL OF DRUG TARGETING, v.26, no.10, pp.884 - 894 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85042134546 | - |
dc.citation.endPage | 894 | - |
dc.citation.startPage | 884 | - |
dc.citation.title | JOURNAL OF DRUG TARGETING | - |
dc.citation.volume | 26 | - |
dc.citation.number | 10 | - |
dc.contributor.affiliatedAuthor | Choi, Jun-Tae | - |
dc.contributor.affiliatedAuthor | Park, Jung-Hwan | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Hyaluronic acid | - |
dc.subject.keywordAuthor | cross-linked particulates | - |
dc.subject.keywordAuthor | micromolding | - |
dc.subject.keywordAuthor | microneedle | - |
dc.subject.keywordAuthor | control of degradation | - |
dc.subject.keywordAuthor | swelling | - |
dc.subject.keywordPlus | TRANSDERMAL DRUG-DELIVERY | - |
dc.subject.keywordPlus | 1,4-BUTANEDIOL DIGLYCIDYL ETHER | - |
dc.subject.keywordPlus | POLYMER MICRONEEDLES | - |
dc.subject.keywordPlus | DERMAL FILLERS | - |
dc.subject.keywordPlus | DISSOLVING MICRONEEDLES | - |
dc.subject.keywordPlus | HYDROGELS | - |
dc.subject.keywordPlus | LINKING | - |
dc.subject.keywordPlus | FABRICATION | - |
dc.subject.keywordPlus | INSULIN | - |
dc.subject.keywordPlus | PATCHES | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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