Microneedles containing cross-linked hyaluronic acid particulates for control of degradation and swelling behaviour after administration into skin
- Authors
- Choi, Jun-Tae; Park, Sang-Jin; Park, Jung-Hwan
- Issue Date
- Nov-2018
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- Hyaluronic acid; cross-linked particulates; micromolding; microneedle; control of degradation; swelling
- Citation
- JOURNAL OF DRUG TARGETING, v.26, no.10, pp.884 - 894
- Journal Title
- JOURNAL OF DRUG TARGETING
- Volume
- 26
- Number
- 10
- Start Page
- 884
- End Page
- 894
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/5267
- DOI
- 10.1080/1061186X.2018.1435664
- ISSN
- 1061-186X
- Abstract
- Microneedles (MN) containing cross-linked hyaluronic acid (X-linked HA) particulates were prepared to control the degradation and swelling behaviour after transdermal drug delivery. The X-linked HA particulates were prepared by cross-linking HA chains and then passing the particulates through a sieve. Then, microneedles were prepared by micromolding method. The rheological properties of X-linked HA were studied. The penetration success rate, mechanical failure and dissolution rate of microneedles containing only hyaluronic acid (HA MN) and microneedles containing X-linked HA were compared. The delivery of fluorescein into the skin with X-linked HA MN was also observed using a confocal microscope. The size of the pulverised particulates in water ranged between 29 and 82 mu m in diameter. The HA MN and X-linked HA MN were 270 mu m in length. X-linked HA MN with fluorescein was inserted to a depth of 90% of the microneedle length successfully. There was no decrease in the penetration success rate for MN with up to 20% content of X-linked HA particulates. X-linked HA MN with up to 20% of particulate content did not change the dissolution time. Delay in degradation of HA, sustained drug release, and swelling behaviour of the skin layer can be obtained by X-linked HA MN.
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Collections - 바이오나노대학 > 바이오나노학과 > 1. Journal Articles
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