Signal Alteration in the Optic Nerve Head on 3D T2-weighted MRI: a Potential Neuroimaging Sign of Glaucomatous Optic Neuropathy
- Authors
- Lee, Jong Yeon; Kwon, Hyo Jeong; Park, Su Jin; Yoo, Chungkwon; Kim, Yong Yeon; Kim, Eung Yeop
- Issue Date
- 2018
- Publisher
- TAYLOR & FRANCIS INC
- Keywords
- Glaucoma; optic nerve head; magnetic resonance imaging; optic-disk cup volume; retinal nerve fiber layer thickness
- Citation
- CURRENT EYE RESEARCH, v.43, no.3, pp.397 - 405
- Journal Title
- CURRENT EYE RESEARCH
- Volume
- 43
- Number
- 3
- Start Page
- 397
- End Page
- 405
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/5319
- DOI
- 10.1080/02713683.2017.1399426
- ISSN
- 0271-3683
- Abstract
- Purpose: To investigate whether a signal alteration (SA) in the optic nerve head (ONH) on 3D T2-weighted magnetic resonance imaging (MRI) is associated with glaucomatous optic neuropathy Materials and Methods: A total of 35 patients with bilateral open-angle glaucoma and 31 age-matched controls underwent 3D high-resolution (0.98 x 0.98 x 1 mm(3)) T2-weighted MRI and detailed ophthalmologic examinations including spectral-domain optical coherence tomography (OCT). Two independent reviewers blinded to subject data determined mild or prominent SA on 3D T2-weighted MRI for the incomplete or complete loss of ocular hypointense continuity in the ONH, respectively. The prevalence of SAs was compared between the two groups with the chi-square test. The OCT measurements were compared among the eyes with a mild or prominent SA and those without an SA using the Kruskal-Wallis test. Results: Of the 35 eyes with glaucoma, 26 eyes (74.3%) exhibited an SA in the ONH, whereas it was observed in 5 (16.1%) of the 31 controls (P < 0.001). The eyes with a prominent SA had a significantly different average retinal nerve fiber layer thickness (P = 0.002) and the ONH parameters except for the disk area (all P < 0.001) than those without an SA. The eyes with a mild SA had a significantly narrower neural rim area, larger cup volume, and larger average and vertical cup-to-disk ratios compared with those without an SA (P = 0.011, 0.003, 0.004, and 0.004, respectively) Conclusions: The SA in the ONH on 3D T2-weighted MRI was significantly more frequent in eyes with open-angle glaucoma than in the controls.
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