Investigation of chemical constituents from Spiraea prunifolia var. simpliciflora and their biological activities
- Authors
- Kim, Chung Sub; Oh, Joonseok; Suh, Won Se; Jang, Sung Wan; Subedi, Lalita; Kim, Sun Yeou; Choi, Sang Un; Lee, Kang Ro
- Issue Date
- Dec-2017
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- Spiraea prunifolia var. simpliciflora; Phenolic glycosides; GIAO NMR chemical shift calculations; Cytotoxicity; Anti-inflammation; Neuroprotection
- Citation
- PHYTOCHEMISTRY LETTERS, v.22, pp.255 - 260
- Journal Title
- PHYTOCHEMISTRY LETTERS
- Volume
- 22
- Start Page
- 255
- End Page
- 260
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/5410
- DOI
- 10.1016/j.phytol.2017.09.014
- ISSN
- 1874-3900
- Abstract
- Quantum mechanics (QM)-based calculations for elucidating full structures of natural compounds are growing in importance and reliability. Two new phenolic glycosides (1 and 2) and 11 known compounds were isolated from the twigs of Spiraea prunifolia var. simpliciflora. The chemical structures of the new compounds (1 and 2) were initially established through different NMR techniques (1H and 13C NMR, COSY, HSQC, and HMBC), HRMS data analysis, and chemical hydrolysis. These structure assignments were further verified by QM-based NMR chemical shift calculations. All of the purified compounds (1-13) were evaluated for their cytotoxicity against four human cancer cell lines (A549, SK-OV-3, SK-MEL-2, and BT549). Those phytochemicals were also evaluated for both anti-inflammatory activity through the measurement of nitric oxide (NO) production levels in lipopolysaccharide (LPS)-stimulated murine microglia BV-2 cell lines and neuroprotective effects via induction of nerve growth factor (NGF) in C6 glioma cells.
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