An ethanol extract of Lysimachia mauritiana exhibits inhibitory activity against hepatitis E virus genotype 3 replication
DC Field | Value | Language |
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dc.contributor.author | Jin, Seong Eun | - |
dc.contributor.author | Kim, Jung-Eun | - |
dc.contributor.author | Kim, Sun Yeou | - |
dc.contributor.author | Park, Bang Ju | - |
dc.contributor.author | Song, Yoon-Jae | - |
dc.date.available | 2020-02-27T16:41:52Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2017-12 | - |
dc.identifier.issn | 1225-8873 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/5418 | - |
dc.description.abstract | Hepatitis E virus (HEV) is an etiological agent of acute hepatitis E, a self-limiting disease prevalent in developing countries. HEV can cause fulminant hepatic failure with high mortality rates in pregnant women, and genotype 3 is reported to trigger chronic hepatitis in immunocompromised individuals worldwide. Screening of plant extracts for compounds with potential anti-HEV effects led to the identification of a 70% ethanol extract of Lysimachia mauritiana (LME) that interferes with replication of the swine HEV genotype 3 replicon. Furthermore, LME significantly inhibited replication of HEV genotype 3 and expression of HEV ORF2 in infected cells without exerting cytotoxic effects. Collectively, our findings demonstrate the potential utility of LME in the development of novel antiviral drugs against HEV infection. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MICROBIOLOGICAL SOCIETY KOREA | - |
dc.relation.isPartOf | JOURNAL OF MICROBIOLOGY | - |
dc.subject | ORF3 PROTEIN | - |
dc.subject | GENUS LYSIMACHIA | - |
dc.subject | PREGNANT-WOMEN | - |
dc.subject | HEV INFECTION | - |
dc.subject | TRANSMISSION | - |
dc.subject | CONSTITUENTS | - |
dc.subject | TRANSPLANT | - |
dc.subject | CIRRHOSIS | - |
dc.subject | SWINE | - |
dc.title | An ethanol extract of Lysimachia mauritiana exhibits inhibitory activity against hepatitis E virus genotype 3 replication | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000417285300010 | - |
dc.identifier.doi | 10.1007/s12275-017-7477-1 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MICROBIOLOGY, v.55, no.12, pp.984 - 988 | - |
dc.identifier.kciid | ART002284830 | - |
dc.identifier.scopusid | 2-s2.0-85037356834 | - |
dc.citation.endPage | 988 | - |
dc.citation.startPage | 984 | - |
dc.citation.title | JOURNAL OF MICROBIOLOGY | - |
dc.citation.volume | 55 | - |
dc.citation.number | 12 | - |
dc.contributor.affiliatedAuthor | Jin, Seong Eun | - |
dc.contributor.affiliatedAuthor | Kim, Jung-Eun | - |
dc.contributor.affiliatedAuthor | Kim, Sun Yeou | - |
dc.contributor.affiliatedAuthor | Park, Bang Ju | - |
dc.contributor.affiliatedAuthor | Song, Yoon-Jae | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | hepatitis E virus | - |
dc.subject.keywordAuthor | antiviral | - |
dc.subject.keywordAuthor | Lysimachia mauritiana | - |
dc.subject.keywordPlus | ORF3 PROTEIN | - |
dc.subject.keywordPlus | GENUS LYSIMACHIA | - |
dc.subject.keywordPlus | PREGNANT-WOMEN | - |
dc.subject.keywordPlus | HEV INFECTION | - |
dc.subject.keywordPlus | TRANSMISSION | - |
dc.subject.keywordPlus | CONSTITUENTS | - |
dc.subject.keywordPlus | TRANSPLANT | - |
dc.subject.keywordPlus | CIRRHOSIS | - |
dc.subject.keywordPlus | SWINE | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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