An ethanol extract of Lysimachia mauritiana exhibits inhibitory activity against hepatitis E virus genotype 3 replication
- Authors
- Jin, Seong Eun; Kim, Jung-Eun; Kim, Sun Yeou; Park, Bang Ju; Song, Yoon-Jae
- Issue Date
- Dec-2017
- Publisher
- MICROBIOLOGICAL SOCIETY KOREA
- Keywords
- hepatitis E virus; antiviral; Lysimachia mauritiana
- Citation
- JOURNAL OF MICROBIOLOGY, v.55, no.12, pp.984 - 988
- Journal Title
- JOURNAL OF MICROBIOLOGY
- Volume
- 55
- Number
- 12
- Start Page
- 984
- End Page
- 988
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/5418
- DOI
- 10.1007/s12275-017-7477-1
- ISSN
- 1225-8873
- Abstract
- Hepatitis E virus (HEV) is an etiological agent of acute hepatitis E, a self-limiting disease prevalent in developing countries. HEV can cause fulminant hepatic failure with high mortality rates in pregnant women, and genotype 3 is reported to trigger chronic hepatitis in immunocompromised individuals worldwide. Screening of plant extracts for compounds with potential anti-HEV effects led to the identification of a 70% ethanol extract of Lysimachia mauritiana (LME) that interferes with replication of the swine HEV genotype 3 replicon. Furthermore, LME significantly inhibited replication of HEV genotype 3 and expression of HEV ORF2 in infected cells without exerting cytotoxic effects. Collectively, our findings demonstrate the potential utility of LME in the development of novel antiviral drugs against HEV infection.
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Collections - 바이오나노대학 > 생명과학과 > 1. Journal Articles
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- 약학대학 > 약학과 > 1. Journal Articles
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