Ceramide and Sphingosine 1-Phosphate in Liver DiseasesCeramide and Sphingosine 1-Phosphate in Liver Diseases
- Other Titles
- Ceramide and Sphingosine 1-Phosphate in Liver Diseases
- Authors
- Woo-Jae Park; 송재휘; 김군태; 박태식
- Issue Date
- May-2020
- Publisher
- 한국분자세포생물학회
- Keywords
- ceramide; fibrosis; insulin resistance; obesity; sphingosine 1-phosphate; steatosis
- Citation
- Molecules and Cells, v.43, no.5, pp.419 - 430
- Journal Title
- Molecules and Cells
- Volume
- 43
- Number
- 5
- Start Page
- 419
- End Page
- 430
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/54264
- DOI
- 10.14348/molcells.2020.0054
- ISSN
- 1016-8478
- Abstract
- The liver is an important organ in the regulation of glucose and lipid metabolism. It is responsible for systemic energy homeostasis. When energy need exceeds the storage capacity in the liver, fatty acids are shunted into nonoxidative sphingolipid biosynthesis, which increases the level of cellular ceramides. Accumulation of ceramides alters substrate utilization from glucose to lipids, activates triglyceride storage, and results in the development of both insulin resistance and hepatosteatosis, increasing the likelihood of major metabolic diseases. Another sphingolipid metabolite, sphingosine 1-phosphate (S1P) is a bioactive signaling molecule that acts via S1P-specific G protein coupled receptors. It regulates many cellular and physiological events. Since an increase in plasma S1P is associated with obesity, it seems reasonable that recent studies have provided evidence that S1P is linked to lipid pathophysiology, including hepatosteatosis and fibrosis. Herein, we review recent findings on ceramides and S1P in obesity-mediated liver diseases and the therapeutic potential of these sphingolipid metabolites.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 바이오나노대학 > 생명과학과 > 1. Journal Articles
- 의과대학 > 의예과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/54264)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.